Hydroxyl radical reactions of (4-hydroxy, 3-methoxy-5-bromophenyl) pentenone, a curcuminoid antioxidant

doi:10.1016/S0969-806X(96)00104-1

Paper

Hydroxyl radical reactions of (4-hydroxy, 3-methoxy-5-bromophenyl) pentenone, a curcuminoid antioxidant

Published 1997 · S. N. Guha, K. Priyadarsini, T. Devasagayam

Radiation Physics and Chemistry

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Abstract

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Curcuminoid antioxidant (4-hydroxy, 3-methoxy-5-bromophenyl) pentenone shows high reactivity with hydroxyl radicals, leading to one electron oxidation at pH 10 and minor oxidation at pH 5, with phenolic form exhibiting minor oxidation.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Hydroxyl radical reactions of (4-hydroxy, 3-methoxy-5-bromophenyl) pentenone, a curcuminoid antioxidant

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References

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This book provides a comprehensive overview of radiation chemistry, covering fundamentals, applications, and biochemistry and radiobiology.

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Curcumin metabolism mainly involves feces, with most of the radioactivity being excreted within 72 hours and some remaining in tissues 12 days after dose.

Citations

Effect of pH on ·OH-induced degradation progress of syringol/syringaldehyde and health effect.

Higher pH levels in aqueous solutions accelerate hydroxylation degradation of syringol and syringaldehyde, reducing toxicities in NOx-rich environments and promoting ring-opening oxygenated chemical production in NOx-poor environments.

Investigations on the antioxidant activity of 5,8-dihydroxy-1,4-dihydro-1,4-methanonaphthalene (DDMN)

DDMN has very good antioxidant activity and may potentially emerge as a good radio-protector.

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The Marcus theory of electron transfer can accurately estimate the reorganization energy for electron transfer from phenols to HRP compounds I and II at pH 7.

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Curcumin is a classical phenolic chain-breaking antioxidant, donating H atoms from phenolic groups rather than the CH(2) group as previously suggested.

Properties of phenoxyl radical of dehydrozingerone, a probable antioxidant

Dehydrozingerone, a methoxy phenol, shows potential antioxidant properties by forming a phenoxyl radical at various pHs, with specific secondary oxidizing radicals causing formation of phenoxyl radicals.