The radioiodination of 4-trimethylsilylbenzyl bromide in acetic acid with no carrier added I-125 and I-123 iodide ion and N-chlorosuccinimide (NCS) is a rapid, high yielding process which produces high specific activity 4-[I-125 or I-123]iodobenzyl bromide. This radiolabelled alkylating agent has been efficiently reacted with N,N-dimethylaniline and triphenylphosphine to generate radiolabelled quaternary ammonium and phosphonium salts, and should be useful for labelling other biologically important molecules which possess suitable nucleophilic functional groups.

I-125 and I-123 labelled iodobenzyl bromide is a rapid, high yielding process for radiolabelling biologically important molecules with suitable nucleophilic functional groups.

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I-125 and I-123 labelled iodobenzyl bromide, a useful alkylating agent for radiolabelling biologically important molecules

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