Paper
Identification and quantification of 6β-hydroxydexamethasone as a major urinary metabolite of dexamethasone in man
Published Feb 1, 1986 · K. Minagawa, Y. Kasuya, S. Baba
Steroids
Q2 SJR score
38
Citations
1
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
6-hydroxydexamethasone is the major urinary metabolite of dexamethasone in men, accounting for over 30% of the dose administered intravenously or orally.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
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Citations
Towards optimization of dexamethasone therapy in the maintenance phase of pediatric acute lymphoblastic leukemia: a population pharmacokinetic and pharmacodynamic study of dexamethasone and metabolite.
Dexamethasone exposure increases hunger in pediatric acute lymphoblastic leukemia patients, with asparaginase co-administration reducing its clearance and metabolization.
2024·0citations·Le Li et al.·European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Across‐species meta‐analysis of dexamethasone pharmacokinetics utilizing allometric and scaling modeling approaches
Dexamethasone pharmacokinetics show moderate variability across species, but distribution parameters are largely conserved across most species.
2021·12citations·Dawei Song et al.·Biopharmaceutics & Drug Disposition
Biopharmaceutics & Drug Disposition
Identification of new substrates for the CYP106A1‐mediated 11‐oxidation and investigation of the reaction mechanism
CYP106A1 catalyzes 11-oxidation of 11-hydroxysteroids, producing novel substrates like prednisolone, dexamethasone, and 11-hydroxyandrostenedione, with ferric peroxoanion as a reactive intermediate.
2015·20citations·F. Kiss et al.·FEBS Letters
FEBS Letters
In Vivo Responses of the Human and Murine Pregnane X Receptor to Dexamethasone in Mice
Human and mouse pregnane X receptors play distinct roles in regulating drug metabolism and hepatotoxicity of dexamethasone, with the latter playing a protective role against hepatotoxicity in mice.
2010·48citations·N. Scheer et al.·Drug Metabolism and Disposition
Drug Metabolism and Disposition