Impact of the Natural Compound Urolithin A on Health, Disease, and Aging.

doi:10.1016/j.molmed.2021.04.009

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Impact of the Natural Compound Urolithin A on Health, Disease, and Aging.

Published May 21, 2021 · D. D’Amico, P. Andreux, P. Valdés

Trends in molecular medicine

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190

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7

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Abstract

Abstract removed due to Elsevier request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

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Key takeawayUrolithin A (UA) enhances cellular health and protects against aging and age-related conditions by increasing mitophagy and mitochondrial function and reducing inflammation.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Impact of the Natural Compound Urolithin A on Health, Disease, and Aging.

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References

Citations

Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity.

Longevity biotechnology, integrating AI, biomarkers, geroscience, and clinical trials, can extend human lifespan by combating age-related diseases and promoting healthy longevity.

Activation of the Gut–Brain Interaction by Urolithin A and Its Molecular Basis

Urolithin A (Uro-A) suppresses age-related cognitive decline by reducing inflammation and altering hippocampal gene expression, potentially through activation of gut-brain interactions.

Involvement of Aryl Hydrocarbon Receptor in Longevity and Healthspan: Insights from Humans, Mice, and C. elegans

Higher levels of aryl hydrocarbon receptor (AHR) gene expression are found in centenarians and may contribute to maintaining physiological balance and promoting healthy aging.

Effect of Urolithin A on Bovine Sperm Capacitation and In Vitro Fertilization

Urolithin A improves bovine sperm motility quality and reduces oxidative stress levels, potentially improving assisted reproductive techniques and addressing reproductive sub/infertility problems.

A Multi-Spectroscopic and Molecular Docking Analysis of the Biophysical Interaction between Food Polyphenols, Urolithins, and Human Serum Albumin

Urolithins, secondary polyphenol metabolites with anti-oxidative, anti-inflammatory, and antidiabetic properties, interact with human serum albumin (HSA) in a spontaneous manner, potentially impacting their pharmacokinetics and dosing regimens.