Impact of the Natural Compound Urolithin A on Health, Disease, and Aging.
Published May 21, 2021 · D. D’Amico, P. Andreux, P. Valdés
Trends in molecular medicine
Q1 SJR score
190
Citations
7
Influential Citations
Abstract
Abstract removed due to Elsevier request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Highly CitedStudy Snapshot
Key takeawayUrolithin A (UA) enhances cellular health and protects against aging and age-related conditions by increasing mitophagy and mitochondrial function and reducing inflammation.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy
Urolithin A, a mitophagy activator, improves muscle function and survival in Duchenne muscular dystrophy models by restoring mitochondrial autophagy and promoting muscle stem cell regeneration.
2021·103citations·Peiling Luan et al.·Science Translational Medicine
Science Translational Medicine
The gut microbiota metabolite urolithin A inhibits NF-κB activation in LPS stimulated BMDMs
Urolithin A shows potential as a therapeutic agent for treating inflammatory diseases by suppressing NF-B and maintaining intracellular calcium and ROS homeostasis.
2021·39citations·Khalid N. M. Abdelazeem et al.·Scientific Reports
Scientific Reports
Effects of urolithins on obesity-associated gut dysbiosis in rats fed on a high-fat diet
Urolithin A and Uro-B effectively reduce body weight and restore serum lipid profile in high-fat diet-induced obesity rats, potentially due to modulation of gut microbial composition.
2021·20citations·Abdulrasheed O Abdulrahman et al.·International Journal of Food Sciences and Nutrition
International Journal of Food Sciences and Nutrition
Urolithin A ameliorates experimental autoimmune encephalomyelitis by targeting aryl hydrocarbon receptor
Urolithin A (URA) effectively suppresses experimental autoimmune encephalomyelitis progression by targeting the Aryl Hydrocarbon Receptor and modulating signaling pathways.
2021·42citations·Pei-Xin Shen et al.·EBioMedicine
EBioMedicine
Urolithin A augments angiogenic pathways in skeletal muscle by bolstering NAD+ and SIRT1
Urolithin A supplementation increases skeletal muscle ATP and NAD+ levels, promoting angiogenesis through a SIRT1-PGC-1 pathway.
2020·43citations·Nandini Ghosh et al.·Scientific Reports
Scientific Reports
Citations
Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity.
Longevity biotechnology, integrating AI, biomarkers, geroscience, and clinical trials, can extend human lifespan by combating age-related diseases and promoting healthy longevity.
2024·0citations·Yu-Xuan Lyu et al.·Aging
Aging
Activation of the Gut–Brain Interaction by Urolithin A and Its Molecular Basis
Urolithin A (Uro-A) suppresses age-related cognitive decline by reducing inflammation and altering hippocampal gene expression, potentially through activation of gut-brain interactions.
2024·0citations·Daiki Kubota et al.·Nutrients
Nutrients
Involvement of Aryl Hydrocarbon Receptor in Longevity and Healthspan: Insights from Humans, Mice, and C. elegans
Higher levels of aryl hydrocarbon receptor (AHR) gene expression are found in centenarians and may contribute to maintaining physiological balance and promoting healthy aging.
2024·0citations·Eva Serna et al.·International Journal of Molecular Sciences
International Journal of Molecular Sciences
Effect of Urolithin A on Bovine Sperm Capacitation and In Vitro Fertilization
Urolithin A improves bovine sperm motility quality and reduces oxidative stress levels, potentially improving assisted reproductive techniques and addressing reproductive sub/infertility problems.
2024·0citations·Manuela Jorge et al.·Animals : an Open Access Journal from MDPI
Animals : an Open Access Journal from MDPI
A Multi-Spectroscopic and Molecular Docking Analysis of the Biophysical Interaction between Food Polyphenols, Urolithins, and Human Serum Albumin
Urolithins, secondary polyphenol metabolites with anti-oxidative, anti-inflammatory, and antidiabetic properties, interact with human serum albumin (HSA) in a spontaneous manner, potentially impacting their pharmacokinetics and dosing regimens.
2024·0citations·Nevena Zelenović et al.·Molecules
Molecules