Impairment due to intake of carisoprodol.

doi:10.1016/J.DRUGALCDEP.2004.01.007

Paper

DOI: 10.1016/J.DRUGALCDEP.2004.01.007

Impairment due to intake of carisoprodol.

Published Jun 11, 2004 · J. Bramness, S. Skurtveit, J. Mørland

Drug and alcohol dependence

Q1 SJR score

Citations

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Observational Study

Study Snapshot

Carisoprodol may impair driving at blood concentration levels above those seen after therapeutic intake, but its metabolite meprobamate does not show a significant impairment effect.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Full text analysis coming soon...

References

DOI: 10.4324/9781003030799-16

Driving under the Influence of Non-Alcohol Drugs.

Driving under the influence of non-alcohol drugs is a major issue, with benzodiazepines, opioids, and illicit drugs being the main contributors, and new detection methods like saliva tests show promise.

2020·71citations·H. Gjerde et al.·Forensic science review

Forensic science review

DOI: 10.1002/9781118548387

Applied Logistic Regression: Hosmer/Applied Logistic Regression

Applied Logistic Regression, Third Edition is a comprehensive guide for building, interpreting, and assessing logistic regression models in health sciences and other fields.

2005·44018citations·D. Hosmer et al.

DOI: 10.1007/s00228-003-0677-0

Testing for benzodiazepine inebriation—relationship between benzodiazepine concentration and simple clinical tests for impairment in a sample of drugged drivers

Simple clinical tests, such as Romberg's test and Romberg's observation, can effectively reveal benzodiazepine impairment in drivers, with potential applications in other contexts.

2003·59citations·J. Bramness et al.·European Journal of Clinical Pharmacology

European Journal of Clinical Pharmacology

DOI: 10.1097/01.FPC.0000054098.48725.88

Association between blood carisoprodol:meprobamate concentration ratios and CYP2C19 genotype in carisoprodol-drugged drivers: decreased metabolic capacity in heterozygous CYP2C191/CYP2C192 subjects?

High carisoprodol : meprobamate ratios in drugged drivers are linked to the presence of mutant CYP2C19 alleles, suggesting a gene dosage effect.

2003·27citations·J. Bramness et al.·Pharmacogenetics

Pharmacogenetics

DOI: 10.1016/S0376-8716(02)00188-6

Clinical impairment of benzodiazepines--relation between benzodiazepine concentrations and impairment in apprehended drivers.

Higher blood concentrations of benzodiazepines are associated with impairment in suspected drugged drivers, suggesting a concentration-related effect on performance.

2002·124citations·J. Bramness et al.·Drug and alcohol dependence

Drug and alcohol dependence

Citations

DOI: 10.1016/j.drugpo.2024.104620

The role of prescribed controlled substance acquisition as potential triggers of opioid overdose: A case-crossover study.

Controlled substance prescription acquisition, particularly opioids combined with carisoprodol and/or benzodiazepines, is a potential trigger of opioid overdose.

2024·0citations·Allen M. Smith et al.·The International journal on drug policy

The International journal on drug policy

DOI: 10.1093/jat/bkae024

Driving under the influence of cocaine and MDMA: Relationship between blood concentrations and results from clinical test of impairment

Cocaine use leads to a relationship between blood concentrations and impairment, while MDMA use shows no such relationship.

2024·0citations·Gunhild Heide et al.·Journal of Analytical Toxicology

Journal of Analytical Toxicology

DOI: 10.1002/phar.2897

Pain management considerations in patients living with both pain syndromes and cardiovascular diseases and disorders

Pharmacotherapy, such as gabapentinoids, opioids, and muscle relaxants, can effectively manage pain and cardiovascular disease in patients with both conditions, while reducing adverse events.

2023·0citations·Emily E. Leppien et al.·Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy

DOI: 10.3390/jcm11041141

Carisoprodol Single and Multiple Dose PK-PD. Part II: Pharmacodynamics Evaluation Method for Central Muscle Relaxants. Double-Blind Placebo-Controlled Clinical Trial in Healthy Volunteers

Carisoprodol acts partly through sedation, with no withdrawal symptoms detected, suggesting low dependence risk following maximum doses and duration of treatment under medical supervision.

2022·1citation·A. Calvo et al.·Journal of Clinical Medicine

Journal of Clinical Medicine

DOI: 10.3126/bibechana.v18i1.29036

Simulated spectra (IR and Raman), NLO, AIM and molecular docking of carisoprodol from DFT approach

Carisoprodol shows partial covalent H-bonding, strong protein-ligand binding activity, and potential as a nonlinear optical material.

2021·5citations·M. Chaudhary et al.·BIBECHANA

BIBECHANA

Impairment due to intake of carisoprodol.

Sign up to use Study Snapshot

References

Driving under the Influence of Non-Alcohol Drugs.

Driving under the influence of non-alcohol drugs is a major issue, with benzodiazepines, opioids, and illicit drugs being the main contributors, and new detection methods like saliva tests show promise.

Applied Logistic Regression: Hosmer/Applied Logistic Regression

Applied Logistic Regression, Third Edition is a comprehensive guide for building, interpreting, and assessing logistic regression models in health sciences and other fields.

Testing for benzodiazepine inebriation—relationship between benzodiazepine concentration and simple clinical tests for impairment in a sample of drugged drivers

Simple clinical tests, such as Romberg's test and Romberg's observation, can effectively reveal benzodiazepine impairment in drivers, with potential applications in other contexts.

Association between blood carisoprodol:meprobamate concentration ratios and CYP2C19 genotype in carisoprodol-drugged drivers: decreased metabolic capacity in heterozygous CYP2C19*1/CYP2C19*2 subjects?

High carisoprodol : meprobamate ratios in drugged drivers are linked to the presence of mutant CYP2C19 alleles, suggesting a gene dosage effect.

Clinical impairment of benzodiazepines--relation between benzodiazepine concentrations and impairment in apprehended drivers.

Higher blood concentrations of benzodiazepines are associated with impairment in suspected drugged drivers, suggesting a concentration-related effect on performance.

Citations

The role of prescribed controlled substance acquisition as potential triggers of opioid overdose: A case-crossover study.

Controlled substance prescription acquisition, particularly opioids combined with carisoprodol and/or benzodiazepines, is a potential trigger of opioid overdose.

Driving under the influence of cocaine and MDMA: Relationship between blood concentrations and results from clinical test of impairment

Cocaine use leads to a relationship between blood concentrations and impairment, while MDMA use shows no such relationship.

Pain management considerations in patients living with both pain syndromes and cardiovascular diseases and disorders

Pharmacotherapy, such as gabapentinoids, opioids, and muscle relaxants, can effectively manage pain and cardiovascular disease in patients with both conditions, while reducing adverse events.

Carisoprodol Single and Multiple Dose PK-PD. Part II: Pharmacodynamics Evaluation Method for Central Muscle Relaxants. Double-Blind Placebo-Controlled Clinical Trial in Healthy Volunteers

Carisoprodol acts partly through sedation, with no withdrawal symptoms detected, suggesting low dependence risk following maximum doses and duration of treatment under medical supervision.

Simulated spectra (IR and Raman), NLO, AIM and molecular docking of carisoprodol from DFT approach

Carisoprodol shows partial covalent H-bonding, strong protein-ligand binding activity, and potential as a nonlinear optical material.

Association between blood carisoprodol:meprobamate concentration ratios and CYP2C19 genotype in carisoprodol-drugged drivers: decreased metabolic capacity in heterozygous CYP2C191/CYP2C192 subjects?