T. Molinski, S. Stanley
Aug 1, 2002
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Influential Citations
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
An abbreviated synthesis of isotopically labelled salmeterol has been achieved. The key improvement utilizes a highly selective Cs2CO3-mediated one-pot alkylation of benzylamine by 6-bromo-1-(4′-phenylbutoxy)hexane to prepare the limiting reagent, 6-N-benzylamino-1-(4′-phenylbutoxy)hexane without overalkylation. The method was applied to synthesis of the title compounds in >97 at% isotopic purity. Copyright © 2002 John Wiley & Sons, Ltd.