Yao Jin-feng, Yang Wen-ge, Shen Lei
2010
Citations
0
Influential Citations
0
Citations
Journal
Chemical Reagents
Abstract
Gabexate mesylate was synthesized from caprolactam by hydrolysis to give 6-aminohexanoic acid,which was subjected to reaction with S-methylisothioureasulfate to obtain 6-guandinyl hexanoic acid,followed by esterification and two steps of acidification,resulting in an overall product yield of 65%.The improved process has the advantages of cheap raw materials used,mild reaction conditions and simple operation.