W. Rui
2011
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Journal
Chinese Journal of Medicinal Chemistry
Abstract
A new synthetic route of gabexate mesylate was designed.And this synthesis method is simple and easy to fulfill the industrial production.6-Aminohexanoic acid hydrochloride(3) was reacted with aminonitrile under certain conditions to give 4.Then 4 was reacted with ethyl hydroxybenzoate in DCC in the presence of DMAP to give the target product.This synthesis method can overcome the disadvantage of traditional synthetic method of expensive raw material and the reaction to overcome the prodution problem.The target compound was identified by 1H-NMR,IR,MS and the yield was raised to 43.1% with 99.2% content.