Li Zong-tao
2008
Citations
0
Influential Citations
1
Citations
Journal
Chinese Journal of Medicinal Chemistry
Abstract
2α,3α-Epoxy-16α-bromo-5α-androstan-17-one(1),an intermediate of rocuronium bromide,was synthesized from epiandrosterone by esterification,elimination,bromination,and epoxidation.The target compound was obtained and identified by 1H-NMR,IR,elemental analysis and MS.The total yield was improved from 33.9% to 55.9%.Compared with the reported process,the improved process is cost-effective,secure,convenient and with higher-yield.