G. Bartholini, W. Burkard, A. Pletscher
Aug 19, 1967
Citations
4
Influential Citations
237
Citations
Quality indicators
Journal
Nature
Abstract
N-(DL-seryl)-N′-(2,3,4-trihydroxybenzyl)-hydrazine (HCl) (Ro 4-4602) is a strong inhibitor of decarboxylase of aromatic amino-acids in vivo and in vitro1,2. The drug counteracts the increase of 5-hydroxytryptamine which is induced by 5-hydroxytryptophan less markedly in the brain than in extracerebral organs. Small doses of Ro 4-4602 have even seemed to enhance this transformation in the brain; this effect could not be explained3,4.