N. Fu, Yaofeng Yuan, Zhong Cao
Jun 10, 2002
Citations
3
Influential Citations
315
Citations
Quality indicators
Journal
Tetrahedron
Abstract
Abstract Indium(III) bromide efficiently catalyzes the three-component coupling of β-keto esters, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones. This new protocol for the Biginelli reaction includes the following important features: produces excellent yields, allows the recycling of catalyst with no loss in its activity, and leads to zero-discharge during the process. The reaction of ethyl acetoacetate, salicylaldehyde and thiuourea produced 13-ethoxycarbonyl-9-methyl-11-thioxo-8-oxa-10,12-diazatricyclo [7.3.1.02,7]-trideca-2,4-6-triene, which had its crystal structure determined by X-ray crystallography.