Induction of cleft palate in mice after ophthalmic administration of hydrocortisone.

doi:10.1016/0041-008X(75)90042-3

Paper

Induction of cleft palate in mice after ophthalmic administration of hydrocortisone.

Published Nov 1, 1975 · P. D. Ballard, E. Hearney, M. Smith

Toxicology and applied pharmacology

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Abstract

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Study Snapshot

Ophthalmic administration of hydrocortisone can induce cleft palate in mice, with higher incidence in medium- and high-dose treatment groups.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Induction of cleft palate in mice after ophthalmic administration of hydrocortisone.

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References

The effect of hydrocortisone on the closure of the palatal shelves in two inbred strains of mice in vivo and in vitro.

Hydrocortisone causes retardation of palatal shelf closure in mice, supporting Fraser's hypothesis, but never prevents it.

Comparative teratogenic study of various corticoid ophthalmics.

Corticosteroids administered via the conjunctival sac during pregnancy can cause fetal anomalies, with hydrocortisone showing the highest risk and cortisone showing the lowest.

Citations

The potential role for corticosterone in the induction of cleft palate in mice after treatment with a selective NK-1 receptor antagonist, casopitant (GW679769B).

Casopitant-induced cleft palate in mice is likely due to increased corticosterone levels, which are in the range previously shown to cause cleft palates in mice.

The Effects of Steroids Upon the Gastrointestinal Tract

Steroid hormones and bile acids play a crucial role in the digestive tract, with glucocorticoids affecting cleft palate development and estrogen promoting intestinal enzyme levels.

Comparative teratogenicity of selected glucocorticoids applied ocularly in mice.

Ocularly applied glucocorticoids, particularly dexamethasone, can increase the risk of cleft palate in fetuses, with their teratogenic potency not being predicted by their anti-inflammatory potency.

Common Disturbances of Vision and Ocular Movement and Surgery of the Eye in the Pregnant Patient

Pregnancy has little significant impact on vision, but complications arise from underlying systemic diseases, pregnancy complications, or preexisting ocular diseases.