Paper
Influence of picolinic acid on seizure susceptibility in mice
Published Jan 1, 2017 · A. Cioczek-Czuczwar, P. Czuczwar, W. Turski
Pharmacological Reports
Q2 SJR score
9
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Non-RCT
Animal Study
Rigorous JournalStudy Snapshot
Piccolinic acid enhances seizure activity and may play a role in the pathogenesis of drug-resistant epilepsy.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases
The kynurenine pathway plays a key role in neurological diseases, with potential for drug development to reduce neurotoxic metabolites and enhance neuroprotective metabolites.
2017·278citations·M. Lovelace et al.·Neuropharmacology
Neuropharmacology
Assessment of the anticonvulsant potency of various benzylamide derivatives in the mouse maximal electroshock-induced seizure threshold model
Nic-BZA, 2F-Pic-BZA, Pic-BZA, Me-Ala-BZA, Iso-Nic-BZA, and Me-Pro-BZA show the highest anticonvulsant potency in the mouse maximal electroshock-induced seizure threshold model.
2016·4citations·M. Swiader et al.·Pharmacological Reports
Pharmacological Reports
Changing the Face of Kynurenines and Neurotoxicity: Therapeutic Considerations
Kynurenines have both neuroprotective and neurotoxic properties, and understanding their role in homeostasis may lead to new therapeutic targets against neurodegenerative diseases.
2015·70citations·Zsuzsanna Bohár et al.·International Journal of Molecular Sciences
International Journal of Molecular Sciences
Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies
Drug resistant epilepsy is defined as failure of adequate trials of two tolerated, appropriately chosen and used antiepileptic drug schedules to achieve sustained seizure freedom.
2009·3737citations·Patrick S L Kwan et al.·Epilepsia
Epilepsia
New derivatives of benzylamide with anticonvulsant activity.
Two new benzylamides show promising anticonvulsant activity, with 1-Cpc-BZA showing MES ED50 of 85.36 mg/kg and cyclopentanecarboxylic acid benzylamide showing pilocarpine ED97 of 270.95 mg
2009·3citations·M. Strupińska et al.·Acta poloniae pharmaceutica
Acta poloniae pharmaceutica
Citations
PicR as a MarR Family Transcriptional Repressor Multiply Controls the Transcription of Picolinic Acid Degradation Gene Cluster pic in Alcaligenes faecalis JQ135
PicR, a MarR-type regulator, efficiently controls the transcription of the pic gene cluster in Alcaligenes faecalis JQ135, enabling efficient utilization of toxic pyridine derivatives.
2022·6citations·Siqiong Xu et al.·Applied and Environmental Microbiology
Applied and Environmental Microbiology
Indolamine 2,3-dioxygenase (IDO) inhibitors as a potential treatment for somatic symptoms
IDO inhibitors may be a potential treatment for somatic symptoms by reducing harmful metabolites and increasing endogenous serotonin and melatonin synthesis.
2022·3citations·Bekir Nihat Doğrul·Medical Hypotheses
Medical Hypotheses
Clinical relevance of depressed kynurenine pathway in episodic migraine patients: potential prognostic markers in the peripheral plasma during the interictal period
Depressed peripheral tryptophan catabolism during the interictal period in migraineurs may act as a trigger for migraine attacks and contribute to glutamate excess induced neurotoxicity.
2021·35citations·Bernadett Tuka et al.·The Journal of Headache and Pain
The Journal of Headache and Pain
Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications
Neuroinflammation and the kynurenine pathway are common links between various CNS disorders, with potential therapeutic implications for developing targeted treatment strategies.
2021·91citations·Mustafa N Mithaiwala et al.·Cells
Cells
Identification and Characterization of a Novel pic Gene Cluster Responsible for Picolinic Acid Degradation in Alcaligenes faecalis JQ135
The pic gene cluster is responsible for the complete degradation of picolinic acid in Alcaligenes faecalis JQ135, providing new insights into microbial catabolism of environmental toxic pyridine derivatives.
2019·19citations·J. Qiu et al.·Journal of Bacteriology
Journal of Bacteriology