Preferential inhibition by 5-bromodeoxyuridine of the synthesis of tyrosine aminotransferase in hepatoma cell cultures.

doi:10.1016/0022-2836(71)90092-1

Paper

DOI: 10.1016/0022-2836(71)90092-1

Preferential inhibition by 5-bromodeoxyuridine of the synthesis of tyrosine aminotransferase in hepatoma cell cultures.

Published Feb 28, 1971 · R. H. Stellwagen, G. Tomkins

Journal of molecular biology

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125

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Abstract

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In Vitro Study

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5-bromodeoxyuridine effectively inhibits tyrosine aminotransferase synthesis in hepatoma cells, potentially affecting their growth and survival.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1016/0014-4827(70)90606-3

The reversible control of animal cell differentiation by the thymidine analog, 5-bromodeoxyuridine.

The thymidine analog 5-bromodeoxyuridine (BUdR) can reversibly suppress cell differentiation in culture, with potential implications for understanding cellular differentiation mechanisms.

1970·113citations·A. Coleman et al.·Experimental cell research

Experimental cell research

DOI: 10.1083/JCB.44.1.134

INHIBITION OF MYOBLAST FUSION AFTER ONE ROUND OF DNA SYNTHESIS IN 5-BROMODEOXYURIDINE

Myogenic cells cultured in 5-bromodeoxyuridine (BUdR) fail to fuse and initiate contractile protein filament synthesis, but have minor effects on cell viability and reproductive integrity.

1970·280citations·R. Bischoff et al.·The Journal of Cell Biology

The Journal of Cell Biology

DOI: 10.1038/224806b0

Control of Degradation and Synthesis of Induced Tyrosine Aminotransferase studied in Hepatoma Cells in Culture

Adrenal steroids increase tyrosine amino-transferase synthesis in hepatoma cells, with a half-time of degradation of 3 to 7 hours depending on the experiment and conditions.

1969·56citations·F. Auricchio et al.·Nature

Nature

DOI: 10.1002/jcp.1040720403

Regulation of specific protein synthesis in cytodifferentiation

The pancreas develops through three regulatory transitions, with specific protein synthesis regulated by diet and hormonal states, and endocrine and exocrine cells interconnected in pancreatic development.

1968·186citations·W. Rutter et al.·Journal of Cellular Physiology

Journal of Cellular Physiology

DOI: 10.1016/0022-2836(68)90234-9

Localization and kinetics of formation of nuclear heterodisperse RNA, cytoplasmic heterodisperse RNA and polyribosome-associated messenger RNA in HeLa cells.

HeLa cells contain three heterogeneous RNA species: nucleoplasmic, cytoplasmic, and polyribosome-associated messenger RNA, with the latter being associated with polyribosomes and containing a 15-minute lag before labeled messenger RNA appears on polyribosomes

1968·499citations·S. Penman et al.·Journal of molecular biology

Journal of molecular biology

DOI: 10.1016/0022-2836(67)90181-7

The role of RNA in the hormonal induction of tyrosine aminotransferase in mammalian cells in tissue culture.

Dexamethasone increases tyrosine aminotransferase activity in hepatoma cells without significantly increasing cellular RNA synthesis or its rate of incorporation.

1967·61citations·T. Gelehrter et al.·Journal of molecular biology

Journal of molecular biology

DOI: 10.2307/3572165

Evidence for dark-reactivation of ultraviolet light damage in mouse L cells.

Caffeine can significantly increase the survival of mouse L cells after ultraviolet light irradiation, similar to the dark-reactivation effect in bacteria with a dark-reactivation system.

1967·210citations·A. Rauth·Radiation research

Radiation research

Citations

DOI: 10.1002/jcp.1041420124

Expression and amplification of cloned rat liver tyrosine aminotransferase in nonhepatic cells

Cloned rat liver tyrosine aminotransferase can be expressed in nonhepatic cells, with potential applications in hepatocellular carcinoma and other diseases.

1990·4citations·K. Kohli et al.·Journal of Cellular Physiology

Journal of Cellular Physiology

DOI: 10.1002/TERA.1420350110

Anomalous neural differentiation induced by 5-bromo-2'-deoxyuridine during organogenesis in the rat.

BrdU incorporation into DNA of primordial embryonic cells significantly affects neurogenesis and neurite outgrowth from neuroblasts, leading to morphological anomalies and anomalous organogenesis.

1987·39citations·W. Biggers et al.·Teratology

Teratology

DOI: 10.1016/0027-5107(85)90188-5

Mutational and pseudomutational effects of 5-bromodeoxyuridine in human lymphoblasts.

BrdUrd induces pseudomutation in human lymphoblasts, causing temporary resistance to thymidine analogues, but does not cause permanent gene locus mutations.

1985·9citations·H. Liber et al.·Mutation research

Mutation research

DOI: 10.1002/ijc.2910330609

Unequal forms of 140–110 kD glycoproteins in B16 melanoma cells with differing detachment properties and metastatic behavior: Influence of bromodeoxyuridine

B16 melanoma cells with different metastatic behaviors show distinct forms of 140-110 kD glycoproteins, suggesting a potential relationship with biological behavior and cell-substratum interactions.

1984·10citations·M. Rieber et al.·International Journal of Cancer

International Journal of Cancer

DOI: 10.1007/BF02776581

Factors affecting the CEA secretion of human adenocarcinoma cell lines into the spent medium

Theophylline, cAMP, PGE2, and INF enhance carcinoembryonic antigen secretion in human adenocarcinoma cell lines, while dbcAMP, DMSO, and BrdUrd do not affect CEA secretion.

1983·2citations·N. Yamaguchi et al.·Gastroenterologia Japonica

Gastroenterologia Japonica

DOI: 10.1111/j.1346-8138.1982.tb01076.x

DIFFERENTIAL EFFECTS OF 5‐BROMODEOXYURIDINE ON B16 MOUSE MELANOMA CELLS

5'-bromodeoxyuridine (BrdU) completely inhibits melanogenesis in B16 mouse melanoma cells, but its effects on cytochrome c oxidase may be too small to detect in our experiments.

1982·2citations·Y. Sugita et al.·The Journal of Dermatology

The Journal of Dermatology

DOI: 10.1128/mcb.2.8.1020-1024.1982

Induction and inhibition of Friend erythroleukemia cell differentiation by pyrimidine analogs: analysis of the requirement for intracellular accumulation and incorporation into DNA

Inhibiting erythroid differentiation requires thymidine analogs incorporated into DNA, and only 5-ethyl-2'-deoxyuridine and 5-bromo-2'-deoxyuridine effectively inhibit dimethyl sulfoxide-induced differentiation.

1982·2citations·J. Bilello et al.·Molecular and Cellular Biology

Molecular and Cellular Biology

DOI: 10.1016/0092-8674(82)90218-5

Variant T47D human breast cancer cells with high progesterone-receptor levels despite estrogen and antiestrogen resistance

T47D human breast cancer cells have high progesterone-receptor levels despite estrogen and antiestrogen resistance, suggesting persistent nuclear estrogen-binding sites may stimulate progesterone production continuously.

1982·252citations·K. Horwitz et al.·Cell

Cell

DOI: 10.1002/jcp.1041100208

Glutamine synthetase induction by glucocorticoids in the glucocorticoid‐sensitive human leukemic cell line CEM‐C7

Glucocorticoids increase glutamine synthetase activity in CEM-C7 cells, but growth inhibition and cytolytic effects are independent responses in this cell line.

1982·49citations·J. Harmon et al.·Journal of Cellular Physiology

Journal of Cellular Physiology