Inhibition of Biological Synthesis of Acetylcholine by Triethylcholine

doi:10.1038/199487B0

Paper

Inhibition of Biological Synthesis of Acetylcholine by Triethylcholine

Published Aug 3, 1963 · G. Bull, B. Hemsworth

Nature

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Abstract

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Study Snapshot

Triethylcholine may cause neuromuscular transmission failure by interfering with acetylcholine synthesis in nerve endings.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Inhibition of Biological Synthesis of Acetylcholine by Triethylcholine

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References

Citations

Drug-induced depletion of acetylcholine in the rabbit corneal epithelium.

Drugs like HC-3 and NVP do not affect the acetylcholine content in the rabbit corneal epithelium, suggesting more than one pool of ACh in the epithelium.

The active structure of hemicholinium inhibiting the biosynthesis of acetylcholine.

The hemiacetal structure of hemicholinium (HC-3) is essential for inhibiting acetylcholine biosynthesis, and any restraint on hemi-acetalization leads to a reduction in activity.

The effects of some hemicholinium-like substances on the chick biventer cervicis muscle preparation.

Chick muscle is more sensitive to post-junctional blocking and pre-junctional facilitatory components of drugs, suggesting a small safety margin in transmitter release at fowl motor nerve-endings.

EFFECTS OF ANALOGUES OF CHOLINE ON NEUROMUSCULAR TRANSMISSION

Hemicholinium No. 3 (HC-3) causes delayed muscular paralysis in laboratory animals, which is restored by choline, but not by related bases.

Effects of quaternary bases and inorganic cations on acetylcholine synthesis in nervous tissue.

TEA, a strong inhibitor of acetylcholine synthesis, is similar to HC-3 in inhibiting acetylcholine synthesis in mouse brain, but its effect is more pronounced in cat superior cervical ganglion.