S. Symchowicz, C. Korduba, J. Veals
1971
Citations
1
Influential Citations
23
Citations
Quality indicators
Journal
Life sciences. Pt. 1: Physiology and pharmacology
Abstract
Abstract Pheniramine and its structural analogs were evaluated for their ability to inhibit dopamine uptake into synaptosomes of rat corpus striatum. A structural activity relationship has been observed. A chlorine or bromine substitution greatly facilitates the inhibitory activity of pheniramine which is further enhanced by demethylation or addition of another halogen. There was no appreciable difference in activity between d- and l- optical isomers of chlorpheniramine or brompheniramine. There was also no correlation between the antihistaminic potency of the compounds and their inhibitory activity on dopamine uptake.