INHIBITION OF IMMEDIATE AND DELAYED HYPERSENSITIVITY IN THE RABBIT BY 6-MERCAPTOPURINE.

doi:10.4049/jimmunol.92.5.754

Paper

INHIBITION OF IMMEDIATE AND DELAYED HYPERSENSITIVITY IN THE RABBIT BY 6-MERCAPTOPURINE.

Published May 1, 1964 · Yves Borel, Robert S. Schwartz

Journal of immunology

Q1 SJR score

76

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2

Influential Citations

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Abstract

Six-mercaptopurine (6-MP) was shown to exert both central and peripheral actions on immune reactions. Its central effects were inhibition of humoral antibody formation and suppression of delayed hypersensitivity. The antimetabolite also blocked the peripheral manifestations of immunity (skin reactions to antigens) without affecting the immune status of the animal. These various actions of 6-MP were brought out under selected conditions of timing, dosage and mode of antigen administration. The processes leading to the development of delayed hypersensitivity were found to be very sensitive to 6-MP; a 4-day course of the drug suppressed this response without inhibiting humoral antibody production or inflammatory responses. The suppression of skin reactions in hyperimmunized rabbits was presumably due to an anti-inflammatory effect of 6-MP; inhibition of the local passive Arthus reaction by 6-MP was a function of the amount of antibody in the test serum. Leukopenia or inanition could not explain these actions of 6-MP.

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Study Snapshot

6-mercaptopurine effectively suppresses delayed hypersensitivity in rabbits without affecting humoral antibody production or inflammatory responses, while also blocking peripheral manifestations of immunity without affecting the animal's immune status.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

INHIBITION OF IMMEDIATE AND DELAYED HYPERSENSITIVITY IN THE RABBIT BY 6-MERCAPTOPURINE.

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References

Citations

Auftreten einer verstärkten Reaktion auf die Testinfektion nach der Vakzinierung mit Aerosolen von inaktiviertem Maul‐ und Klauenseuche‐(MKS‐)Virus

Finely dispersed aerosols of inactivated foot-and-mouth disease virus vaccines provide weak protection in guinea pigs and mice, but this protection is not constant and can be transmitted through cell-free lung extracts.

THE EFFECT OF AZATHIOPRINE ON MONONUCLEAR BLOOD CELLS CULTURED IN VITRO

Azathioprine, an immunosuppressive drug, suppresses lymphocyte rosette formation and macrophage digestion in vitro, with potential implications for treating lymphoma.

Augmentation of tumor immunity by 6-MPG, a water-soluble derivative of 6-mercaptopurine, in mice.

6-MPG, a water-soluble derivative of 6-mercaptopurine, shows potential as an anti-tumor immunopotentiator with an improved therapeutic index.

Mechanisms in the suppression of delayed hypersensitivity in the guinea pig by 6-mercaptopurine. II: Kinetic and morphologic studies on the monocyte-macrophage component.

6-mercaptopurine suppresses delayed hypersensitivity in guinea pigs by targeting monocyte-macrophage cells, with its effects primarily affecting newly synthesized bone marrow-derived monocytes and affecting macrophage function and distribution.

Immunosuppressive therapy of idiopathic thrombocytopenic purpura.

Immunosuppressive drugs show promise in treating idiopathic thrombocytopenic purpura, but their role has not yet superseded conventional management with steroids and splenectomy.