Selective inhibition of the inducible nitric oxide synthase by aminoguanidine.

doi:10.1016/S0076-6879(96)68042-2

Paper

DOI: 10.1016/S0076-6879(96)68042-2

Selective inhibition of the inducible nitric oxide synthase by aminoguanidine.

Published 1993 · T. P. Misko, W. M. Moore, T. Kasten

European journal of pharmacology

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422

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

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Study Snapshot

Aminoguanidine selectively inhibits the cytokine-inducible isoform of nitric oxide synthase, potentially aiding in the treatment of diseases characterized by excessive nitric oxide production.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Histological assessment of the local effect of different concentrations of aminoguanidine hydrochloride on bone healing in rats

Selective iNOS inhibitors like aminoguanidine hydrochloride can promote local bone healing in rats, with 20% concentration showing the best results.

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Rapid gut dysbiosis induced by stroke exacerbates brain infarction in turn

Ischemic stroke rapidly triggers gut dysbiosis, which in turn exacerbates brain infarction, and restoring gut dysbiosis with aminoguanidine, superoxide dismutase, and tungstate can potentially improve stroke outcomes.

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Differences in cNOS/iNOS Activity during Resistance to Trypanosoma cruzi Infection in 5-Lipoxygenase Knockout Mice

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Effect of nitric oxide on boar sperm motility, membrane integrity, and acrosomal status during semen storage.

Low nitric oxide levels are necessary for normal boar sperm function during semen storage, with 0.625 mM aminoguanidine increasing sperm motility and acrosome integrity.

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