The inhibition of lipid peroxidation by cinnarizine. Possible implications to its therapeutic and side-effects.

doi:10.1016/0006-2952(91)90070-L

Paper

DOI: 10.1016/0006-2952(91)90070-L

The inhibition of lipid peroxidation by cinnarizine. Possible implications to its therapeutic and side-effects.

Published Mar 1, 1991 · A. Fernandes, P. Filipe, H. Coelho

Biochemical pharmacology

Q1 SJR score

Citations

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

Cinnarizine inhibits lipid peroxidation in various biological systems, potentially explaining its antivasoconstrictor properties and red-cell deformability.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Full text analysis coming soon...

References

DOI: 10.1073/PNAS.86.4.1398

Dopamine turnover and glutathione oxidation: implications for Parkinson disease.

Increased dopamine turnover in Parkinson's disease may be linked to oxidative stress, suggesting oxidative stress may play a role in the disease's natural history.

1989·421citations·M. B. Spina et al.·Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America

DOI: 10.1016/0006-2952(88)90116-5

Protection of cardiac membrane phospholipid against oxidative injury by calcium antagonists.

Calcium antagonists can protect cardiac membrane lipids from oxidative damage, potentially contributing to their pharmacology and therapeutic activities.

1988·87citations·D. Janero et al.·Biochemical pharmacology

Biochemical pharmacology

DOI: 10.1096/fasebj.1.5.2824268

Oxidants and human disease: some new concepts 1

Oxidants play a significant role in the pathology of several human diseases, including rheumatoid arthritis, reperfusion injury, immune injury, and cerebral trauma or ischemia, with promising new therapeutic approaches.

1987·1003citations·B. Halliwell·The FASEB Journal

The FASEB Journal

DOI: 10.1136/JNNP.50.6.804

Aggravation of Parkinson's disease by cinnarizine.

Cinnarizine can significantly worsen mobility in Parkinson's disease patients, making it a potential drug to aggravate the condition.

1987·24citations·J. M. Martí Massó et al.·Journal of Neurology, Neurosurgery & Psychiatry

Journal of Neurology, Neurosurgery & Psychiatry

DOI: 10.1212/WNL.37.5.881

Flunarizine‐ and cinnarizine‐induced extrapyramidal reactions

Cinnarizine and flunarizine, both calcium blockers, can cause extrapyramidal reactions and depression, and should be considered potentially risky drugs for treating vertigo.

1987·94citations·F. Micheli et al.·Neurology

Neurology

DOI: 10.1016/S0140-6736(86)91223-7

PARKINSONISM, TARDIVE DYSKINESIA, AKATHISIA, AND DEPRESSION INDUCED BY FLUNARIZINE

Flunarizine can cause Parkinson's disease, tardive dyskinesia, akathisia, and depression, with some patients showing partial or complete improvement after withdrawal.

1986·134citations·C. Chouza et al.·The Lancet

The Lancet

DOI: 10.1111/J.1365-2125.1986.TB02859.X

Calcium antagonists and their mode of action: an historical overview.

Calcium antagonists effectively manage various cardiac disorders by slowing calcium entry through voltage-activated channels and interfering with Na+ transport.

1986·47citations·W. Nayler et al.·British journal of clinical pharmacology

British journal of clinical pharmacology

Citations

DOI: 10.1016/j.carbpol.2019.115421

Antioxidant, antiradical, and antimicrobial activities of polysaccharides obtained by microwave-assisted extraction method: A review.

Microwave-assisted extraction of polysaccharides shows strong antioxidant, antiradical, and antimicrobial properties, making them potential for use in functional foods and nutraceuticals.

2020·214citations·M. Mirzadeh et al.·Carbohydrate polymers

Carbohydrate polymers

DOI: 10.1201/9780203913611.CH4

Drug-induced Parkinsonism

Drug-induced Parkinsonism (DIP) is dose-dependent and related to individual susceptibility to neuroleptics, with akinetic rigid symptoms and lesser resting tremor in elderly patients.

2004·3citations·K. Sethi

DOI: 10.1023/A:1010944919952

Flavonoids and urate antioxidant interplay in plasma oxidative stress

Some flavonoids can protect endogenous urate from oxidative degradation, and their antioxidant synergy with urate may help protect against atherosclerosis complications.

2001·64citations·P. Filipe et al.·Molecular and Cellular Biochemistry

Molecular and Cellular Biochemistry

DOI: 10.1093/jn/131.3.1016S

The effects of aged garlic extract on lipid peroxidation and the deformability of erythrocytes.

Aged garlic extract improves microcirculation and rheological blood properties by preserving erythrocyte structure and function, not only through antioxidant processes but also through glycolysis pathway and membrane stabilization.

2001·67citations·T. Moriguchi et al.·The Journal of nutrition

The Journal of nutrition

DOI: 10.1002/1531-8257(199905)14:3<534::AID-MDS1032>3.0.CO;2-Z

Cinnarizine‐induced parkinsonism: Ten years later

Cinnarizine-induced parkinsonism (CIP) is a common and often resolved condition in drug-induced parkinsonism patients, with symptoms typically resolving after drug withdrawal.

1999·52citations·A. Negrotti et al.·Movement Disorders

Movement Disorders