N. I. Fadeeva, I. Leneva, E. K. Panisheva
2004
Citations
1
Influential Citations
4
Citations
Journal
Pharmaceutical Chemistry Journal
Abstract
A large group of substances with clear antiviral activity is known to exist among derivatives of 5-hydroxyindole [2, 5], including the antiviral preparation arbidol, l-methyl-2phenylthiomethyl-3-ethoxycarbonyl-4-dimethylaminomethyl-5-hydroxy-6-bromoindole (I) [i]. In continuation of our studies on the synthesis of 5-hydroxyindole derivatives, which are directed towards discovering new compounds with antiviral activity, we report here the synthesis of two groups of compounds based on a 3-ethoxycarbonyl-5-hydroxy-6-bromoindole fragment substituted in position I with a methyl or aryl group, and with a sulfur-containing residue position 2. The latter was either a substituted pyrimidyl-2-thiomethyl fragment or a thioureidomethyl group; the first of these imitates the arylthiomethyl fragment characteristic of arbidol and many other substances with antiviral activity [5]; compounds containing thioureides have recently been found to have considerable antiviral activity [6, 7].