INHIBITORY ACTION OF 4-HYDROXYLAMINOPYRIDINE 1-OXIDE ON THE TRANSFORMING DEOXYRIBONUCLEIC ACID IN BACILLUS SUBTILIS

doi:10.1266/JJG.44.31

Paper

INHIBITORY ACTION OF 4-HYDROXYLAMINOPYRIDINE 1-OXIDE ON THE TRANSFORMING DEOXYRIBONUCLEIC ACID IN BACILLUS SUBTILIS

Published 1969 · H. Adachi, M. Inuzuka, M. Tomoeda

The Japanese Journal of Genetics

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Abstract

The in vitro effect of 4-nitropyridine 1-oxide (4NPO) and its reductive erivatives on the transforming DNA in Bacillus subtilis was investigated. Among six compounds used, only 4-hydroxylaminopyridine 1-oxide (4HAPO) was effective to inhibit the transforming activity of DNA. The inhibition took place only in the presence of air.This led to a conclusion that 4HAPO itself is not the ultimate compound in the inhibition process of the transforming DNA but an oxidation product possibly of free radical character may be primarily responsible for this event.

Study Snapshot

4-hydroxylaminopyridine 1-oxide (4HAPO) effectively inhibits transforming DNA in Bacillus subtilis, but an oxidation product, possibly a free radical, may be primarily responsible for this inhibition.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

INHIBITORY ACTION OF 4-HYDROXYLAMINOPYRIDINE 1-OXIDE ON THE TRANSFORMING DEOXYRIBONUCLEIC ACID IN BACILLUS SUBTILIS

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References

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Polynuclear aromatic hydrocarbons, 4nitroquinoline 1oxides, and various dyes show specific interactions with DNA, with purines being active sites of interaction.

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4-Nitroquinoline l-oxide (4-NQO) and its derivatives can induce phage formation in lysogenic bacteria, potentially highlighting their potential as carcinogenic agents.

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Microorganisms reduce 4-nitroquinoline 1-oxide's ultraviolet absorption maximum due to reduction of nitro group at 4-position and smaller reduction of N-Obond in 1-position.

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Citations

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Posttranslational modifications in proteins can alter electrophoretic mobility and may cause ontogenetic and tissue-specific expression, confounding interpretations of protein electrophoretic data.

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Maternal effects on enzyme phenotypes in hybrid frog embryos are mainly due to enzymes present in the egg prior to fertilization, not continued synthesis directed by stable messenger RNA.