New insights on the use of desipramine as an inhibitor for acid ceramidase

doi:10.1016/j.febslet.2006.07.071

Paper

DOI: 10.1016/j.febslet.2006.07.071

New insights on the use of desipramine as an inhibitor for acid ceramidase

Published Aug 21, 2006 · S. Elojeimy, D. Holman, Xiang Liu

FEBS Letters

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101

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Abstract

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In Vitro Study

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Study Snapshot

Desipramine's mechanism of action involves inhibiting acid ceramidase, which is a key enzyme in cancer cell growth and survival.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1038/sj.cgt.7700965

Combined therapeutic use of AdGFPFasL and small molecule inhibitors of ceramide metabolism in prostate and head and neck cancers: a status report

AdGFPFasL and small molecule inhibitors of ceramide metabolism show potential in prostate and head and neck cancers, but gene delivery remains the major obstacle to successful cancer treatment.

2006·56citations·James S. Norris et al.·Cancer Gene Therapy

Cancer Gene Therapy

DOI: 10.1074/jbc.M604713200

Acid Ceramidase but Not Acid Sphingomyelinase Is Required for Tumor Necrosis Factor-α-induced PGE2 Production*

Acid ceramidase plays a novel role in the TNF-induced PGE2 pathway, and its inhibition by desipramine may not be specific for acid sphingomyelinase.

2006·63citations·Y. Zeidan et al.·Journal of Biological Chemistry

Journal of Biological Chemistry

DOI: 10.1016/J.BMC.2005.12.035

Chloroquine inhibits cell growth and induces cell death in A549 lung cancer cells.

Chloroquine inhibits A549 lung cancer cell growth at lower concentrations by increasing lysosome volume, while at higher concentrations it induces apoptosis and necrosis, with PC-PLC possibly playing a role in these processes.

2006·167citations·Chuandong Fan et al.·Bioorganic & medicinal chemistry

Bioorganic & medicinal chemistry

DOI: 10.1667/RR3436.1

Chloroquine-Mediated Radiosensitization is due to the Destabilization of the Lysosomal Membrane and Subsequent Induction of Cell Death by Necrosis

Chloroquine-mediated radiosensitization is due to destabilization of lysosomal membranes and increased cell death by necrosis, rather than apoptosis alone.

2005·72citations·Helen Zhao et al.

DOI: 10.1038/nrc1411

Biologically active sphingolipids in cancer pathogenesis and treatment

Ceramide acts as a tumor-suppressor lipid, while S1P promotes cancer development, paving the way for potential anticancer therapies.

2004·1242citations·B. Ogretmen et al.·Nature Reviews Cancer

Nature Reviews Cancer

Citations

DOI: 10.3390/antiox13080968

Vitamin C-Dependent Uptake of Non-Heme Iron by Enterocytes, Its Impact on Erythropoiesis and Redox Capacity of Human Erythrocytes

Vitamin C-dependent enterocytes uptake non-heme iron, impacting erythropoiesis and redox capacity of human erythrocytes.

2024·1citation·Xia Pan et al.·Antioxidants

Antioxidants

DOI: 10.3390/ijms231911178

Emerging Roles of Ceramides in Breast Cancer Biology and Therapy

Ceramide turnover plays a crucial role in breast cancer progression and therapy resistance, offering potential for new therapeutic strategies to improve patient outcomes.

2022·15citations·Purab Pal et al.·International Journal of Molecular Sciences

International Journal of Molecular Sciences

DOI: 10.3389/fmolb.2022.864618

Involvement of Ceramide Metabolism in Cerebral Ischemia

Ceramide metabolism plays a crucial role in acute ischemic stroke, suggesting potential new therapeutic approaches for this devastating disease.

2022·12citations·A. Ouro et al.·Frontiers in Molecular Biosciences

Frontiers in Molecular Biosciences

DOI: 10.1016/j.blre.2022.100950

Harnessing the power of sphingolipids: Prospects for acute myeloid leukemia.

Targeting dysregulated sphingolipid metabolism shows potential in improving acute myeloid leukemia patient care and outcomes.

2022·14citations·J. Ung et al.·Blood reviews

Blood reviews

DOI: 10.1101/2022.01.19.22269391

COVID-19 and its clinical severity are associated with alterations of plasma sphingolipids and enzyme activities of sphingomyelinase and ceramidase

COVID-19 patients experience a severity-dependent dysregulation of sphingolipid homeostasis, with increased enzyme activities leading to ceramide elevation and decreased enzymes reducing ceramide levels.

2022·6citations·C. Mühle et al.

DOI: 10.3389/fimmu.2021.737988

Siglec-8 Signals Through a Non-Canonical Pathway to Cause Human Eosinophil Death In Vitro

Siglec-8 causes eosinophil cell death through a complex non-canonical pathway, involving multiple signaling molecules and regulating cell-surface CD11b integrin levels.

2021·15citations·Daniela J. Carroll et al.·Frontiers in Immunology

Frontiers in Immunology

DOI: 10.14814/phy2.14928

Sphingomyelinase decreases transepithelial anion secretion in airway epithelial cells in part by inhibiting CFTR‐mediated apical conductance

Basolateral sphingomyelinase decreases CFTR-mediated transepithelial anion secretion in airway epithelial cells, potentially impacting CFTR function and causing lung failure.

2021·6citations·Kirsten A Cottrill et al.·Physiological Reports

Physiological Reports

DOI: 10.3390/ijms22169001

Acid Sphingomyelinase, a Lysosomal and Secretory Phospholipase C, Is Key for Cellular Phospholipid Catabolism

Acid sphingomyelinase (ASM) plays a crucial role in cellular phospholipid catabolism and plays a role in various metabolic disorders.

2021·24citations·Bernadette Breiden et al.·International Journal of Molecular Sciences

International Journal of Molecular Sciences