Insights into the Mechanism of Thiol Triggered COS/H2S Release from N-Dithiasuccinoyl Amines.

doi:10.1021/acs.joc.0c00559

Paper

Insights into the Mechanism of Thiol Triggered COS/H2S Release from N-Dithiasuccinoyl Amines.

Published Jun 4, 2020 · Shengchao Zhou, Yujie Mou, Miao Liu

The Journal of organic chemistry

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13

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0

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Abstract

The hydrolysis of COS to form H2S by carbonic anhydrase has been demonstrated to be a viable strategy to deliver H2S in biological system. Herein, we describe N-dithiasuccinoyl amines as thiol-triggered COS/H2S donors. Notably, thiol species especially GSH and homocysteine can trigger the release of both COS and H2S directly from several specific analogues via an unexpected mechanism. Importantly, two representative analogues Dts-1 and Dts-5 show intracellular H2S release, and Dts-5 imparts potent anti-inflammatory effects in LPS challenged microglia cells. In conclusion, N-dithiasuccinoyl amine could serve as promising COS/H2S donors for either H2S biology studies or H2S-based therapeutics development.

Study Snapshot

N-dithiasuccinoyl amines show potential as thiol-triggered COS/H2S donors for H2S biology studies and H2S-based therapeutics development.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Insights into the Mechanism of Thiol Triggered COS/H2S Release from N-Dithiasuccinoyl Amines.

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