R. Ding, Y. Tayrouz, K. Riedel
Jul 1, 2004
Citations
3
Influential Citations
172
Citations
Quality indicators
Journal
Clinical Pharmacology & Therapeutics
Abstract
Ritonavir is a potent in vitro inhibitor of several cytochrome P450 isozymes and ABC transporters including the efflux pump P‐glycoprotein (P‐gp). This study assessed the effect of repetitive ritonavir administration on digoxin distribution and total and renal digoxin clearance as a marker for P‐gp activity in vivo.