A. Claxton, C. Wilkinson, L. Baker
Jul 1, 2012
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Influential Citations
2
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Quality indicators
Journal
Alzheimer's & Dementia
Abstract
properties. Molecular modeling studies have indicated the central fused acridine ring undergoes favourable interactions within the catalytic site of AChE enzyme. Preliminary data on their ability to inhibit both AChE and BuChEs, their ability to chelate metals and antioxidant properties along with detailed enzyme-ligand binding investigations will be discussed. Conclusions: It is anticipated that our research should lead to the development of novel class of disease-modifying agents to treat AD by developing novel (i) heterocyclic small molecules possessing dual ChE (AChE/BuChE) inhibition; (ii) identify metal chelating and antioxidant pharmacophores in the design of small molecule therapeutics to treat AD.