The clinical investigation of citrullus colocynthis (L.) schrad fruit in treatment of Type II diabetic patients: a randomized, double blind, placebo‐controlled clinical trial

doi:10.1002/ptr.2754

Paper

The clinical investigation of citrullus colocynthis (L.) schrad fruit in treatment of Type II diabetic patients: a randomized, double blind, placebo‐controlled clinical trial

Published Aug 1, 2009 · H. F. Huseini, F. Darvishzadeh, R. Heshmat

Phytotherapy Research

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160

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10

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Abstract

Citrullus colocynthis (L.) Schrad fruit is an herbal medicine used by traditional herbalists for the treatment of diabetes in Iran. To determine its efficacy and toxicity, a 2 month clinical trial was conducted in 50 type II diabetic patients. Two groups of 25 each under standard antidiabetic therapy, received 100 mg C. colocynthis fruit capsules or placebos three times a day, respectively. The patients were visited monthly and glycosylated hemoglobin (HbA1c), fasting blood glucose, total cholesterol, LDL, HDL, triglyceride, aspartate transaminase, alanine transaminase, alkaline phosphatase, urea and creatinine levels were determined at the beginning and after 2 months. The results showed a significant decrease in HbA1c and fasting blood glucose levels in C. colocynthis treated patients. Other serological parameters levels in both the groups did not change significantly. No notable gastrointestinal side effect was observed in either group. In conclusion, C. colocynthis fruit treatment had a beneficial effect on improving the glycemic profile without severe adverse effects in type II diabetic patients. Further clinical studies are recommended to evaluate the long‐term efficacy and toxicity of C. colocynthis in diabetic patients. Copyright © 2009 John Wiley & Sons, Ltd.

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Study Snapshot

Citrullus colocynthis fruit treatment improves glycemic profile without severe adverse effects in type II diabetic patients.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

The clinical investigation of citrullus colocynthis (L.) schrad fruit in treatment of Type II diabetic patients: a randomized, double blind, placebo‐controlled clinical trial

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References

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Clinical algorithms can guide the use of nutritional and botanical medicines in treating type 2 diabetes, providing a framework for future research and clinical practice.

The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: a randomized, double‐blind, placebo‐controlled, clinical trial

Silymarin treatment for 4 months in type II diabetic patients significantly improves their glycemic profile compared to placebo.

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Antioxidants, essential fatty acids, carnitine, vitamins, phytochemicals, and trace elements may enhance glycemic control and reduce chronic complications in diabetic patients.

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The macrocyclic binuclear oxovanadium complex effectively reduces oxidative stress in the pancreas of diabetic rats, protecting beta cells and lipid peroxide levels.

Biochemical effects of Citrullus colocynthis in normal and diabetic rats

Oral administration of Citrullus colocynthis seed extract can reduce some toxic effects of streptozotocin in diabetic rats, but does not affect blood urea nitrogen levels.

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The homeopathic remedy Hepeel® and its constituent plant tinctures exhibit specific antioxidative, antiproliferative, and biochemical effects on HepG2 cells, suggesting potential hepatoprotective and tumoristatic effects.

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Oxidative stress plays a significant role in the onset and progression of diabetes, with potential protective effects from antioxidants.

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Screening for type 2 diabetes is currently inconclusive, with biochemical tests performing better than risk assessment questionnaires, but the optimal interval for screening remains unknown.

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Feeding rats a mixture of Citrullus colocynthis fruits and Nerium oleander leaves can cause more severe symptoms and death, with diarrhea being a prominent sign.

Citations

Two new cucurbitane-type triterpenoid saponins from the fruit of Citrullus colocynthis.

Two new cucurbitane-type triterpenoid saponins, 1,2,20,22-trihydroxy-16,23(R)-epoxycucurbita-1,5,24-triene-3,11-dione 2-O--D-glucopyrano

Exploring Folklore Ecuadorian Medicinal Plants and Their Bioactive Components Focusing on Antidiabetic Potential: An Overview

Ecuadorian medicinal plants, particularly Bryophyllum gastonis-bonnieri, have potential antidiabetic properties due to their bioactive phytochemicals, which can benefit the local economy and industries seeking natural products.

Herbal therapy in diabetes mellitus: A review

Medicinal plants like Allium sativum, Cinnamomum verum, Trigonella graecum foenum, Silybum marianus, Citrullus colocynthis, Abelmoschus esculentus, Eryngium, Coriandrum sativum

Bioactivity-Guided Isolation and Antihypertensive Activity of Citrullus colocynthis Polyphenols in Rats with Genetic Model of Hypertension

Citrullus colocynthis polyphenol-rich fractions show antihypertensive and antioxidant properties, reducing blood pressure and oxidative stress in a spontaneous hypertensive rat model.

Pathophysiology of diabetic hepatopathy and molecular mechanisms underlying the hepatoprotective effects of phytochemicals.

Herbal agents, particularly phenolic compounds, show beneficial effects on diabetic hepatopathy, improving liver function and reducing complications in diabetic patients.

Citrullus colocynthis (L.) Schrad.: A Promising Pharmaceutical Resource for Multiple Diseases

Citrullus colocynthis fruit has potential as a pharmaceutical resource for various diseases due to its insecticide, antitumor, and antidiabetic effects.

Citrullus colocynthis (L.) Schrad: A Promising Prospect Towards Pharmacology, Traditional Uses, and Potential Applications

Citrullus colocynthis (L.) Schrad has significant potential for pharmaceutical and nutraceutical applications due to its antidiabetic, anticancer, antioxidant, antimicrobial, and anti-inflammatory properties.

Effect of fruit on glucose control in diabetes mellitus: a meta-analysis of nineteen randomized controlled trials

Increasing fruit intake significantly reduces fasting blood glucose concentration in patients with diabetes, so they should eat more fruits while maintaining their total energy intake.