W. Curran
Nov 6, 1973
Citations
0
Influential Citations
5
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
The reaction of 1,2,3,5-telrahydro-6-methoxy-1 -[2-(4-methoxy-1,4-eyelohexadien-1 -yl)eth-yl]-l-methyl-7-isoquinolinol (12) with hot phosphoric acid afforded (±)-tetrahydro-homoglazio-vine (14) in good yield. Similar treatment of 1,2,3,4-tetrahydro-6-methoxy-l -[2-(4-methoxy-1,4-cyelohexadien-l-yl)methyl]-2-methyl-7-isoquinolinol (13) did not produce the desired (±)-tetra-hydroglaziovine (18) but rather a mixture of diastereomeric 4,5,6,6aϵ,7,7aϵ,8,9,11, 11aϵ-deca-hydro-l-hydroxy-2-metlu>xy-6-methyl-10H-dibenzo[(de,g]quinolin-l-ones (16 and 17) was obtained.