M. Lamani, K. R. Prabhu
Sep 13, 2011
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Journal
The Journal of organic chemistry
Abstract
A facile metal-free route of oxidative amination of benzoxazole by activation of C-H bonds with secondary or primary amines in the presence of catalytic iodine in aqueous tert-butyl hydroperoxide proceeds smoothly at ambient temperature under neat reaction condition to furnish the high yield of the aminated product. This user-friendly method to form C-N bonds produces tertiary butanol and water as the byproduct, which are environmentally benign. The application of the methodology is demonstrated by synthesizing therapeutically active benzoxazoles.