Sensory and pulmonary irritation with exposure to methyl isocyanate.

doi:10.1016/0041-008X(86)90209-7

Paper

DOI: 10.1016/0041-008X(86)90209-7

Sensory and pulmonary irritation with exposure to methyl isocyanate.

Published Feb 1, 1986 · J. Ferguson, M. Schaper, M. F. Stock

Toxicology and applied pharmacology

Q2 SJR score

Citations

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Highly Cited

Study Snapshot

Methyl isocyanate is a potent sensory and pulmonary irritant, causing respiratory rate decreases in mice at concentrations between 0.5 and 7.6 ppm.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Full text analysis coming soon...

References

DOI: 10.1111/J.1600-0773.1985.TB01271.X

Propyl ether. II. Pulmonary irritation and anaesthesia.

Propyl ether causes pulmonary irritation and anaesthesia, with a threshold limit value of about 100 p.p.m., and no impurities in technical grade ether influenced the responses.

2009·18citations·G. Nielsen et al.·Acta pharmacologica et toxicologica

Acta pharmacologica et toxicologica

DOI: 10.1016/0041-008X(85)90182-6

Pulmonary and sensory irritation of diphenylmethane-4,4'- and dicyclohexylmethane-4,4'-diisocyanate.

MDI and SMDI are primarily pulmonary irritants, with recommended TLV-TWAs for industry being no higher than 0.3 and 0.4 mg/m3, respectively.

1985·37citations·D. Weyel et al.·Toxicology and applied pharmacology

Toxicology and applied pharmacology

DOI: 10.1016/0041-008X(82)90238-1

Sensory irritation, pulmonary irritation, and acute lethality of a polymeric isocyanate and sensory irritation of 2,6-toleune diisocyanate.

The DES-N polymeric isocyanate is primarily a pulmonary irritant, with a maximum concentration permitted in industry at 1 mg/m3 and a recommended exposure limit for 2,6-toluene diisocyanate at 0.04 mg/m3 (0.006 ppm).

1982·57citations·D. Weyel et al.·Toxicology and applied pharmacology

Toxicology and applied pharmacology

DOI: 10.1016/0041-008X(81)90285-4

Comparison of some mono- and diisocyanates as sensory irritants.

Aromatic and aliphatic diisocyanates have comparable potency as sensory irritants, while aromatic monoisocyanates are slightly less potent and aliphatic monoisocyanates are the least potent.

1981·32citations·G. Sangha et al.·Toxicology and applied pharmacology

Toxicology and applied pharmacology

DOI: 10.1016/0041-008X(79)90408-3

Sensory irritation by toluene diisocyanate in single and repeated exposures.

Toluene diisocyanate (TDI) is the most potent sensory irritant tested, with cumulative effects from repeated exposures at or above 0.023 ppm, suggesting a reduced Threshold Limit Value for industrial exposure.

1979·79citations·G. Sangha et al.·Toxicology and applied pharmacology

Toxicology and applied pharmacology

Citations

DOI: 10.1007/s11224-020-01552-6

Adsorption of methyl isocyanate on M4 (M=Fe, Ni, and Cu) cluster-decorated graphene and vacancy graphene: a DFT-D2 study

Metal cluster-decorated graphene and vacancy graphene show enhanced methyl isocyanate adsorption, with high adsorption energy and large Hirshfeld charge transfer.

2020·13citations·Jogender et al.·Structural Chemistry

Structural Chemistry

DOI: 10.1016/j.mrfmmm.2018.03.005

Effect of age at exposure on chromosome abnormalities in MIC-exposed Bhopal population detected 30 years post-disaster.

Age-related increase in chromosomal abnormalities in blood-lymphocytes is observed in MIC-exposed survivors, with severe exposure causing higher abnormalities.

2018·4citations·B. Ganguly et al.·Mutation research

Mutation research

DOI: 10.1007/s11356-017-0865-6

Spectrum of health condition in methyl isocyanate (MIC)-exposed survivors measured after 30 years of disaster

Methyl isocyanate (MIC) exposure has long-term health effects on survivors, with reproductive, ophthalmic, and respiratory effects being prevalent, but the incidence of health problems has declined.

2018·15citations·B. Ganguly et al.·Environmental Science and Pollution Research

Environmental Science and Pollution Research

DOI: 10.1016/j.vascn.2014.03.174

Optimizing the use of methods and measurement endpoints in respiratory safety pharmacology.

Optimizing the use of methods and measurement endpoints in respiratory safety pharmacology studies can enhance understanding of drug-induced effects on respiratory function and help design more effective studies.

2014·8citations·D. Murphy·Journal of pharmacological and toxicological methods

Journal of pharmacological and toxicological methods

DOI: 10.1016/j.yrtph.2013.11.010

Respiratory safety pharmacology - current practice and future directions.

Current respiratory safety pharmacology practices focus on pulmonary ventilation, but other parameters and models are needed to assess drug-induced respiratory dysfunction in animal models.

2014·15citations·D. Murphy·Regulatory toxicology and pharmacology : RTP

Regulatory toxicology and pharmacology : RTP

Sensory and pulmonary irritation with exposure to methyl isocyanate.

Sign up to use Study Snapshot

References

Propyl ether. II. Pulmonary irritation and anaesthesia.

Propyl ether causes pulmonary irritation and anaesthesia, with a threshold limit value of about 100 p.p.m., and no impurities in technical grade ether influenced the responses.

Pulmonary and sensory irritation of diphenylmethane-4,4'- and dicyclohexylmethane-4,4'-diisocyanate.

MDI and SMDI are primarily pulmonary irritants, with recommended TLV-TWAs for industry being no higher than 0.3 and 0.4 mg/m3, respectively.

Sensory irritation, pulmonary irritation, and acute lethality of a polymeric isocyanate and sensory irritation of 2,6-toleune diisocyanate.

The DES-N polymeric isocyanate is primarily a pulmonary irritant, with a maximum concentration permitted in industry at 1 mg/m3 and a recommended exposure limit for 2,6-toluene diisocyanate at 0.04 mg/m3 (0.006 ppm).

Comparison of some mono- and diisocyanates as sensory irritants.

Aromatic and aliphatic diisocyanates have comparable potency as sensory irritants, while aromatic monoisocyanates are slightly less potent and aliphatic monoisocyanates are the least potent.

Sensory irritation by toluene diisocyanate in single and repeated exposures.

Toluene diisocyanate (TDI) is the most potent sensory irritant tested, with cumulative effects from repeated exposures at or above 0.023 ppm, suggesting a reduced Threshold Limit Value for industrial exposure.

Citations

Adsorption of methyl isocyanate on M4 (M=Fe, Ni, and Cu) cluster-decorated graphene and vacancy graphene: a DFT-D2 study

Metal cluster-decorated graphene and vacancy graphene show enhanced methyl isocyanate adsorption, with high adsorption energy and large Hirshfeld charge transfer.

Effect of age at exposure on chromosome abnormalities in MIC-exposed Bhopal population detected 30 years post-disaster.

Age-related increase in chromosomal abnormalities in blood-lymphocytes is observed in MIC-exposed survivors, with severe exposure causing higher abnormalities.

Spectrum of health condition in methyl isocyanate (MIC)-exposed survivors measured after 30 years of disaster

Methyl isocyanate (MIC) exposure has long-term health effects on survivors, with reproductive, ophthalmic, and respiratory effects being prevalent, but the incidence of health problems has declined.

Optimizing the use of methods and measurement endpoints in respiratory safety pharmacology.

Optimizing the use of methods and measurement endpoints in respiratory safety pharmacology studies can enhance understanding of drug-induced effects on respiratory function and help design more effective studies.

Respiratory safety pharmacology - current practice and future directions.

Current respiratory safety pharmacology practices focus on pulmonary ventilation, but other parameters and models are needed to assess drug-induced respiratory dysfunction in animal models.

Effect of age at exposure on chromosome abnormalities in MIC-exposed Bhopal population detected 30 years post-disaster.