Isobavachalcone Attenuates MPTP-Induced Parkinson's Disease in Mice by Inhibition of Microglial Activation through NF-κB Pathway

doi:10.1371/journal.pone.0169560

Paper

Isobavachalcone Attenuates MPTP-Induced Parkinson's Disease in Mice by Inhibition of Microglial Activation through NF-κB Pathway

Published Jan 6, 2017 · Haoran Jing, Shao-xia Wang, Min Wang

PLoS ONE

Q1 SJR score

74

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2

Influential Citations

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Abstract

Parkinson's disease (PD) is a complex multi-system and age-related neurodegenerative disorder. The intervention targeting neuroinflammation in PD patients is one effective strategy to slow down or inhibit disease progression. Microglia-mediated inflammatory response plays an important role in Parkinson's, Alzheimer's and other cerebral diseases. Isobavachalcone is a main component of Chinese herb medicine Psoralea corylifolia, which function includes immunoregulation, anti-oxidation and the regulation of β-amyloid (Aβ42) deposited in hippocampus in Alzheimer's patients. Whether it has the therapeutic effect on Parkinson's disease, however, is unclear. In this study, we found that isobavachalcone could effectively remit Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP), prolong the residence time of mice on Rota-rod and alleviate the neuronal necrosis. It also inhibited the over-activation of microglia, and decreased the expression of IL-6 and IL-1β in the brain of PD mice. In vitro, isobavachalcone could inhibit nuclear factor-kappaB (NF-κB) pathway through inhibiting the LPS-induced transfer of NF-κB subunit from cytoplasm to nucleus in BV-2 cells. Isobavachalcone decreased the LPS-induced oxidative stress and the expression of inflammatory cytokines, and provided a neuroprotective effect by antagonizing microglia-mediated inflammation. Our results indicated that isobavachalcone may be a candidated drug against Parkinson's disease with great clinical potential.

Non-RCT

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Rigorous Journal

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Study Snapshot

Isobavachalcone effectively reduces Parkinson's disease in mice by inhibiting microglial activation and NF-B pathway, suggesting it as a potential candidate drug against Parkinson's disease.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Isobavachalcone Attenuates MPTP-Induced Parkinson's Disease in Mice by Inhibition of Microglial Activation through NF-κB Pathway

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References

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Synthesis and anti-cancer activity evaluation of novel prenylated and geranylated chalcone natural products and their analogs.

Novel prenylated and geranylated chalcone natural products show promising anti-cancer activity, with bavachalcone showing the most potent cytotoxic activity against K562 human tumor cell line.

Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2.

Fructus Psoraleae contains natural compounds with potent inhibitory effects on human carboxylesterase 2, which may help treat various diseases like asthma, diarrhea, and osteoporosis.

LRRK2 and neuroinflammation: partners in crime in Parkinson’s disease?

LRRK2 mutations may contribute to neuroinflammation and neurodegeneration in Parkinson's disease by sensitizing microglia cells to pro-inflammatory states.

Citations