Isothiocyanates as novel cytotoxic and cytostatic agents: molecular pathway on human transformed and non-transformed cells.

doi:10.1016/J.BCP.2004.03.044

Paper

Isothiocyanates as novel cytotoxic and cytostatic agents: molecular pathway on human transformed and non-transformed cells.

Published Sep 15, 2004 · C. Fimognari, M. Nüsse, F. Berti

Biochemical pharmacology

Q1 SJR score

47

Citations

2

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Study Snapshot

Isothiocyanates, found in human diet, show potential as cancer chemopreventive agents by inducing apoptosis and modulating cell-cycle progression, with MTBITC showing the most promising effects on non-transformed human cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Isothiocyanates as novel cytotoxic and cytostatic agents: molecular pathway on human transformed and non-transformed cells.

Sign up to use Study Snapshot

References

Citations

The recent advances of glucosinolates and their metabolites: Metabolism, physiological functions and potential application strategies

Glucosinolates and their metabolites from Brassicaceae plants show potential health benefits, but environmental factors can affect their biotransformation to isothiocyanates, potentially impairing their health benefits.

Discovery of Sulforaphane as an Inducer of Ferroptosis in U-937 Leukemia Cells: Expanding Its Anticancer Potential

Sulforaphane (SFN) shows potential as an anticancer agent by inducing both apoptosis and ferroptosis in acute myeloid leukemia cells, with its antileukemic activity mediated through both ferroptotic and apoptotic cell death modal

Natural and Synthetic Isothiocyanates Possess Anticancer Potential Against Liver and Prostate Cancer In Vitro

Dietary and synthetic isothiocyanates show potential as anticancer agents against liver and prostate cancer cells in vitro.

Antioxidant effects of sulforaphane in human HepG2 cells and immortalised hepatocytes.

Sulforaphane shows potential anti-cancer effects in human hepatocytes and hepatoma cells, but its non-specific regulation of cell death and survival may present risks and cause chemo-resistance in tumor cells.

Differentiating Antiproliferative and Chemopreventive Modes of Activity for Electron‐Deficient Aryl Isothiocyanates against Human MCF‐7 Cells

Electron-deficient aryl isothiocyanates show potential antiproliferative and chemopreventive properties against human MCF-7 breast cancer cells, with potential for further development.