Isoxazole Derivatives as Regulators of Immune Functions

doi:10.3390/molecules23102724

Paper

Isoxazole Derivatives as Regulators of Immune Functions

Published Oct 1, 2018 · M. Zimecki, Urszula Bąchor, M. Mączyński

Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

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Abstract

In this review, we present reports on the immunoregulatory properties of isoxazole derivatives classified into several categories, such as immunosuppressive, anti-inflammatory, immunoregulatory, and immunostimulatory compounds. The compounds were tested in various models using resident cells from rodents and humans, cell lines, and experimental animal disease models corresponding to human clinical situations. Beneficial features of the described isoxazole derivatives include low toxicity and good bioactivity at low doses. In a majority of studies, the activities of investigated compounds were comparable or even higher than registered reference drugs. Whenever possible, a plausible mechanism of action of the investigated compounds and their potential therapeutic utility were proposed. Among the described compounds, particular attention was paid to the class of immune stimulators with a potential application in chemotherapy patients.

Literature Review

Study Snapshot

Isoxazole derivatives show promising immunoregulatory properties, with low toxicity and good bioactivity at low doses, potentially benefiting chemotherapy patients.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Isoxazole Derivatives as Regulators of Immune Functions

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