Zhang Yi-zh
2006
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Journal
International Journal of Dermatology and Venereology
Abstract
This review describes two kinds of new anti-HSV drugs,4-oxo-dihydroquinolines and cytosine-phosphate-guanine(CpG)-containing oligodeoxynucleotide(ODN),which have been developed in recent years.Many studies show that 4-oxo-dihydroquinolines have good oral bioavailability and plasma clearance,and they suppress both the DNA polymerase of HSV and virus replication in the cells.CpG ODN plays its anti-HSV role not by the direct suppression of the virus-infected cells but through the stimulation of immune system.Both the two kinds of new drugs have been experimentally verified to have good suppres- sive effects on HSV.