Kinetics of 8-2 fluorotelomer alcohol and its metabolites, and liver glutathione status following daily oral dosing for 45 days in male and female rats.

doi:10.1016/j.cbi.2009.03.015

Paper

Kinetics of 8-2 fluorotelomer alcohol and its metabolites, and liver glutathione status following daily oral dosing for 45 days in male and female rats.

Published Jul 15, 2009 · W. Fasano, L. Sweeney, M. Mawn

Chemico-biological interactions

Q1 SJR score

72

Citations

4

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Highly Cited

Study Snapshot

Daily oral dosing of 8-2 fluorotelomer alcohol for 45 days in rats does not cause liver damage or nephropathy, suggesting that GSH depletion is not a relevant mode of action in the liver.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Kinetics of 8-2 fluorotelomer alcohol and its metabolites, and liver glutathione status following daily oral dosing for 45 days in male and female rats.

Sign up to use Study Snapshot

References

8-2 fluorotelomer alcohol aerobic soil biodegradation: pathways, metabolites, and metabolite yields.

Aerobic degradation of 8-2 fluorotelomer alcohol in soils produces unique metabolites, including 7-3 acid, which may help distinguish between 8-2 FTOH biodegradation and other sources of PFOA in environmental samples.

Bioactivation of fluorotelomer alcohols in isolated rat hepatocytes.

Fluorotelomer alcohols (FTOHs) toxicity is linked to electrophilic aldehydes or acids through GSH depletion and protein carbonylation, with further research needed on protein modification.

Perfluorooctane sulphonate (PFOS) and perfluorooctanoic acid (PFOA) in human breast milk: results of a pilot study.

Fully breastfed infants are unlikely to exceed the recommended tolerable daily intake of perfluorinated compounds (PFOS and PFOA) from breast milk.

Perfluorinated compounds in house dust from Ohio and North Carolina, USA.

Perfluorinated compounds, particularly PFOS and PFOA, are present in house dust at levels that may represent an important pathway for human exposure.

Estimating Consumer Exposure to PFOS and PFOA

Consumers in North America and Europe are likely exposed to PFOS and PFOA from contaminated foods, impregnation sprays, treated carpets, and coated food contact materials, with children experiencing higher uptake doses.

Citations