Paper
Lacosamide displays potent antinociceptive effects in animal models for inflammatory pain
Published Apr 1, 2006 · T. Stöhr, E. Krause, N. Selve
European Journal of Pain
Q1 SJR score
58
Citations
1
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
Lacosamide shows potent antinociceptive effects in animal models for inflammatory pain, suggesting it may be active against various forms of acute and chronic inflammatory pain in humans.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
Allodynia and Hyperalgesia in Adjuvant-Induced Arthritic Rats: Time Course of Progression and Efficacy of Analgesics
Analgesics like morphine and tramadol effectively reduce pain in CFA-induced arthritis rats, while acetaminophen, carbamazepine, and gabapentin show limited efficacy.
2003·172citations·Y. Nagakura et al.·Journal of Pharmacology and Experimental Therapeutics
Journal of Pharmacology and Experimental Therapeutics
Antinociceptive Activity of the N-Methyl-d-aspartate Receptor Antagonist N-(2-Indanyl)-glycinamide Hydrochloride (CHF3381) in Experimental Models of Inflammatory and Neuropathic Pain
CHF3381 shows potential as an effective treatment for peripheral painful neuropathies, with potential benefits beyond those of gabapentin and memantine.
2003·85citations·G. Villetti et al.·Journal of Pharmacology and Experimental Therapeutics
Journal of Pharmacology and Experimental Therapeutics
Gabapentin and Pregabalin Can Interact Synergistically with Naproxen to Produce Antihyperalgesia
Gabapentin and pregabalin can interact synergistically or additively to reverse thermal hyperalgesia associated with peripheral inflammation, offering potential therapeutic advantages for chronic inflammatory pain treatment.
2002·163citations·R. Hurley et al.·Anesthesiology
Anesthesiology
Use of anticonvulsants for treatment of neuropathic pain
Anticonvulsants show promise in treating neuropathic pain, with newer drugs like gabapentin and lamotrigine showing promising results.
2002·295citations·M. Backonja·Neurology
Neurology
A comparison of the anti-nociceptive effects of voltage-activated Na+ channel blockers in the formalin test.
Voltage-activated Na+ channel blockers can reduce nociceptive behavior in the formalin test, with mexiletine, lubeluzole, and riluzole showing specific anti-nociceptive effects.
2002·57citations·G. Blackburn-Munro et al.·European journal of pharmacology
European journal of pharmacology
Citations
Epilepsy treatment in neuro-oncology: A rationale for drug choice in common clinical scenarios
New anti-seizure medications have revolutionized neuro-oncology treatment by adapting to individual patient features and reducing side effects.
2022·8citations·J. M. Sánchez-Villalobos et al.·Frontiers in Pharmacology
Frontiers in Pharmacology
Off‐label use of lacosamide, an alternative for the treatment of neuropathic pain
Lacosamide is an offlabel treatment for neuropathic pain, particularly trigeminal neuralgia, due to its unique action on sodium channels, which slows down neuronal hyperexcitability without affecting normal physiological activity.
2022·1citation·A. Alcántara Montero·Headache: The Journal of Head and Face Pain
Headache: The Journal of Head and Face Pain
Therapeutic effects of Lacosamide in a rat model of traumatic brain injury: A histological, biochemical and electroencephalography monitoring study.
Lacosamide treatment at different doses shows potential neuroprotective effects in a rat model of traumatic brain injury, reducing inflammation, apoptosis, and oxidative stress.
2021·5citations·Mesut Mete et al.·Injury
Injury
Biopsychosocial Aspects in Individuals with Acute and Chronic Rotator Cuff Related Shoulder Pain: Classification Based on a Decision Tree Analysis
Biopsychosocial aspects can effectively classify individuals with acute and chronic rotator cuff related shoulder pain, revealing distinct phenotypes and their interactions.
2020·22citations·M. N. Haik et al.·Diagnostics
Diagnostics
Druggability of CRMP2 for neurodegenerative diseases.
CRMP2 plays a crucial role in regulating microtubule network and ion channel trafficking, contributing to various diseases like cancer, neurodegenerative diseases, chronic pain, and bipolar disorder.
2020·17citations·R. Khanna et al.·ACS chemical neuroscience
ACS chemical neuroscience
Emerging Drugs for the Treatment of Amyotrophic Lateral Sclerosis: A Focus on Recent Phase 2 Trials
Recent phase 2 clinical trials show promise in targeting neuroinflammation, proteinopathies, and oxidative stress, potentially improving ALS treatment outcomes.
2020·8citations·A. Barp et al.·Expert Opinion on Emerging Drugs
Expert Opinion on Emerging Drugs
Analgesic and antiallodynic activity of novel anticonvulsant agents derived from 3-benzhydryl-pyrrolidine-2,5-dione in mouse models of nociceptive and neuropathic pain.
Novel anticonvulsant agents derived from 3-benzhydryl-pyrrolidine-2,5-dione show analgesic and antiallodynic effects in mouse models of nociceptive and neuropathic pain.
2019·4citations·A. Rapacz et al.·European journal of pharmacology
European journal of pharmacology
Pregabalin and lacosamide ameliorate paclitaxel-induced peripheral neuropathy via inhibition of JAK/STAT signaling pathway and Notch-1 receptor
Lacosamide and pregabalin effectively manage paclitaxel-induced peripheral neuropathy without motor adverse effects, by inhibiting oxidative stress, inflammation, and apoptosis without motor impairment.
2018·43citations·Khaled F. Al-Massri et al.·Neurochemistry International
Neurochemistry International
A Well-Tolerated and Effective Antiepileptic Drug for Patients With Myasthenia Gravis at Last?
Lacosamide is a well-tolerated and effective antiepileptic drug for patients with myasthenia gravis, overcoming the issue of drug-induced worsening of symptoms.
2018·3citations·J. M. Sánchez-Villalobos et al.·Clinical Neuropharmacology
Clinical Neuropharmacology