C. Kumara, P. Naik, D. JagadeeshPrasad
2015
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Journal
International Journal of Advanced Research in Chemical Science
Abstract
A series of novel 3-tert-butyl-7-benzyl-4H-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-ones(5a-h) were prepared by condensing 4-amino-6-tert-butyl-3-sulfanyl-1,2,4-triazin-5(4H)-one (1) with various substituted phenyl acetic acids in the presence of phosphorus oxychloride at 150 C (Scheme 2). 4-amino-6-tert-butyl-3sulfanyl-1,2,4-triazin-5(4H)-one (1) was prepared by treating 3,3-dimethyl-2-oxobutanoic acid (trimethyl pyruvic acid) (1) with thiocarbohydrazide (2) in ethanol as solvent for 12h (Scheme 1). The products obtained were confirmed by H-NMR, FTIR and Mass Spectral studies. The novel derivatives were evaluated for the growth inhibition (antimicrobial) property against certain bacterial and fungal pathogens. The derivatives have also been screened for their potency of mosquito larvicidal activity.