Mahdi Mollaei, S. M. Ghoreishi, Asma Khoobi
Feb 1, 2020
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Measurement
Abstract
Abstract This study is the first report for simultaneous determination of calcium folinate (CF) and methotrexate (MTX) in nano-molar level using a simple modified carbon paste electrode (CPE) by cationic surfactants. N-dodecylpyridinium chloride (DPC) as a cationic surfactant has not yet been used successfully as a modifier in any simultaneous electrochemical measurements. Initially, the performance of DPC for modification of the electrode surface is compared with a well-known cationic surfactant. Then, after revealing the superiority of DPC, it is used as a modifier. Under the optimum conditions, using multivariate optimization, the oxidation peak current of CF in the presence of 10.0 µM MTX is linear in the concentration range of 0.1–10.0 µM with a detection limit of 17.5 nM. Under similar conditions, the oxidation peak current of MTX in the presence of 10.0 µM CF is linear in the concentration range of 0.05–10.0 µM with a detection limit of 9.3 nM.