H. Irie, Masataka Nishimura, Morihiro Yoshida
1989
Citations
0
Influential Citations
12
Citations
Journal
Journal of The Chemical Society-perkin Transactions 1
Abstract
Lewis acids such as boron trifluoride–diethyl ether and aluminium chloride catalyze the reaction of alcohols and sulphonamides with isocyanates, affording carbamates and sulphonylureas, respectively, in acceptable yield. Applied to the formation of diastereoisomeric carbamates from chiral alcohols using Pirkle's reagents, [(R)- and (S)-1-(1 -naphthyl)ethyl isocyanate (NPEI)], this technique provides a convenient method for determination of enantiomeric purity.