Liensinine inhibited gastric cancer cell growth through ROS generation and the PI3K/AKT pathway

doi:10.7150/jca.32691

Paper

Liensinine inhibited gastric cancer cell growth through ROS generation and the PI3K/AKT pathway

Published Oct 19, 2019 · Jia-hua Yang, Kun Yu, Xian-ke Si

Journal of Cancer

Q2 SJR score

29

Citations

1

Influential Citations

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Abstract

Liensinine, an isoquinoline alkaloid extracted from the seed embryo of Nelumbo nucifera Gaertn, has been shown to exhibit various phrenological effects, including anti‑cancer activity. The aim of this study is to investigate the effects and mechanisms of liensinine in human gastric cancer cells. In this study, we found liensinine can significantly inhibit gastric cancer cell proliferation in vitro and in vivo. Liensinine inducedgastric cancer cell apoptosis by increasing cleaved PARP, caspased 3 and caspased 9. Moreover, liensinine induced cycle arrest by downregulatingcyclinD1/cyclin‑dependent kinase4 and phosphorylated protein kinase B. Furthermore, we found liensinine increases ROS levels and inhibits the PI3K/AKT pathway. These data suggested that liensinine might represent a novel and effective agent against gastric cancer.

In Vitro Study

Rigorous Journal

Study Snapshot

Liensinine effectively inhibits gastric cancer cell growth by increasing ROS levels and inhibiting the PI3K/AKT pathway, suggesting it as a potential novel anti-cancer agent.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Liensinine inhibited gastric cancer cell growth through ROS generation and the PI3K/AKT pathway

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Citations

Liensinine inhibits IL-1β-stimulated inflammatory response in chondrocytes and attenuates papain-induced osteoarthritis in rats.

Liensinine, a component of lotus seeds, effectively inhibits inflammation and attenuates osteoarthritis progression in rats by inhibiting the NF-B signaling pathway.

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