The neurobiological link between OCD and ADHD

doi:10.1007/s12402-014-0146-x

Paper

The neurobiological link between OCD and ADHD

Published Jul 14, 2014 · S. Brem, E. Grünblatt, R. Drechsler

Attention Deficit and Hyperactivity Disorders

Q2 SJR score

86

Citations

1

Influential Citations

Full textSemantic Scholar

Abstract

Obsessive compulsive disorder (OCD) and attention deficit hyperactivity disorder (ADHD) are two of the most common neuropsychiatric diseases in paediatric populations. The high comorbidity of ADHD and OCD with each other, especially of ADHD in paediatric OCD, is well described. OCD and ADHD often follow a chronic course with persistent rates of at least 40–50 %. Family studies showed high heritability in ADHD and OCD, and some genetic findings showed similar variants for both disorders of the same pathogenetic mechanisms, whereas other genetic findings may differentiate between ADHD and OCD. Neuropsychological and neuroimaging studies suggest that partly similar executive functions are affected in both disorders. The deficits in the corresponding brain networks may be responsible for the perseverative, compulsive symptoms in OCD but also for the disinhibited and impulsive symptoms characterizing ADHD. This article reviews the current literature of neuroimaging, neurochemical circuitry, neuropsychological and genetic findings considering similarities as well as differences between OCD and ADHD.

Literature Review

Highly Cited

Study Snapshot

Key takeawayOCD and ADHD share a high comorbidity rate, with similar executive functions affected in both disorders, and both disorders may be linked to deficits in brain networks.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

The neurobiological link between OCD and ADHD

Sign up to use Study Snapshot

References

Citations

Thalamocortical dysrhythmia and reward deficiency syndrome as uncertainty disorders

ADHD and Risk of Precocious Puberty: Considering the Impact of MPH

Obsessive-compulsive disorder from a cognitive-behavioural point of view

A systematic review and meta-analysis for the efficacy of transcranial direct current stimulation (tDCS) in OCD treatment: A non-pharmacological approach to clinical interventions

Clarifying the prevalence of OCD: A response to reader comments.

Externally orienting cues improve cognitive control in OCD.

Obsessive-Compulsive Disorder (OCD): A Comprehensive Review of Diagnosis, Comorbidities, and Treatment Approaches

Comparison of Toxoplasma Gondii IgG Antibody Levels in Children and Adolescents with OCD and ADHD with Healthy Controls: A Cross-Sectional Study