S. T. Yang, L. Wilken, C. Clark
1987
Citations
0
Influential Citations
3
Citations
Journal
Journal of pharmaceutical and biomedical analysis
Abstract
The stability of eseroline, the hydrolysis product of physostigmine under aerobic conditions, was studied by liquid chromatography. A reversed-phase, ion-pair technique was used to separate eseroline from its degradation products. The degradation of eseroline in phosphate buffer solutions of pH 6.91, 7.40, 7.98, 8.41 and 8.94 appears to follow first-order kinetics; the rate constant increased with an increase in pH. The degradation appears to follow specific base catalysis.