In vitro autoradiographic localization of amylin binding sites in rat brain

doi:10.1016/0306-4522(94)90388-3

Paper

DOI: 10.1016/0306-4522(94)90388-3

In vitro autoradiographic localization of amylin binding sites in rat brain

Published Sep 1, 1994 · P. Sexton, G. Paxinos, M. Kenney

Neuroscience

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280

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

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Study Snapshot

Amylin binding sites in rat brain are present in areas potentially involved in appetite, fluid and electrolyte homeostasis, autonomy function, and mood regulation.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Citations

DOI: 10.1016/j.biochi.2024.10.012

Central nervous system pathways targeted by amylin in the regulation of food intake.

Amylin and related peptide salmon calcitonin target various central nervous system pathways to regulate food intake, potentially enhancing obesity treatment with cagrilintide.

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Changes in hippocampal volume, synaptic plasticity and amylin sensitivity in an animal model of type 2 diabetes are associated with increased vulnerability to amyloid-beta in advancing age

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The processing intermediate of human amylin, pro-amylin(1-48), has in vivo and in vitro bioactivity.

Pro-amylin(1-48) has biological activity and may play a role in the development of future amylin-based drugs.

2024·2citations·Giulia Mazzini et al.·Biophysical chemistry

Biophysical chemistry