Lyme Disease: A Role for Coenzyme Q10 Supplementation?

doi:10.3390/antiox11040667

Paper

Lyme Disease: A Role for Coenzyme Q10 Supplementation?

Published Mar 30, 2022 · D. Mantle, Nadia Turton, I. Hargreaves

Antioxidants

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Abstract

Lyme disease results from a bacterial infection following a bite from an infected tick. Patients are initially treated with antibiotics; however, in cases where antibiotic treatment is delayed, or when patients do not respond to antibiotic treatment, fatigue may develop alongside problems affecting the nervous system, cardiovascular system, and joints. It is thought that most of the damage to these tissues results from the excessive inflammatory response of the host, involving a self-reinforcing cycle of mitochondrial dysfunction, oxidative stress and inflammation. In this article, we review the potential role of supplementary coenzyme Q10 (CoQ10) in mediating the pathogenic mechanism underlying Lyme disease, on the basis of its role in mitochondrial function, as well as its anti-inflammatory and antioxidant actions.

Rigorous Journal

Study Snapshot

Coenzyme Q10 supplementation may play a role in mediating the pathogenic mechanism underlying Lyme disease, due to its role in mitochondrial function, anti-inflammatory, and antioxidant actions.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Lyme Disease: A Role for Coenzyme Q10 Supplementation?

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References

Coenzyme Q10 and Immune Function: An Overview

CoQ10 supplementation may improve immune system function by playing various roles, including electron carrier, antioxidant, and anti-inflammatory agent.

Lyme Disease Pathogenesis.

Lyme disease Borrelia cause disease in humans and non-reservoir vertebrates primarily through inducing inflammation, with mechanisms for dissemination, colonization, and immune evasion playing key roles in pathogenesis.

Lyme Disease in Humans.

Lyme disease is a tick-borne zoonosis causing tissue damage and symptomatology, with a high prognosis for early treatment and a small risk of developing post-treatment Lyme disease (PTLD).

The Effect of Cellular Coenzyme Q10 Deficiency on Lysosomal Acidification

Cellular CoQ10 deficiency may impair lysosomal acidification, and restoring CoQ10 levels can restore lysosomal pH.

Complement Evasion by Lyme Disease Spirochetes.

Lyme disease spirochetes evade complement by producing outer-surface lipoproteins that bind host complement components and manipulate their native activities.

Citations

Rehabilitation of children with Lyme arthritis

Combining magnetic laser therapy with antibacterial therapy improves pain status and accelerates rehabilitation in children with Lyme arthritis.