Macrophage-stimulating activity of polysaccharides extracted from fruiting bodies of Coriolus versicolor (Turkey Tail Mushroom).

doi:10.1089/JMF.2006.9.175

Paper

Macrophage-stimulating activity of polysaccharides extracted from fruiting bodies of Coriolus versicolor (Turkey Tail Mushroom).

Published Jul 5, 2006 · S. Jeong, Byung‐Keun Yang, Guk-Nam Kim

Journal of medicinal food

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19

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1

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Abstract

The macrophage-stimulating effect of polysaccharides extracted from Coriolus versicolor (Turkey Tail mushroom) was investigated, and their effectiveness was compared with that of lipopolysaccharide (LPS). The purified polysaccharide (CV-S2-Fr.I) of C. versicolor obtained by Sepharose CL-6B gel chromatography stimulated macrophage lysosomal enzyme activity by 250% at a concentration of 100 microg/mL, which was higher than that of LPS at the same concentration. When CV-S2-Fr.I was used in combination with interferon-gamma, there was a marked cooperative induction of nitric oxide production. However, CV-S2-Fr.I had no effect on nitric oxide production by itself. The proportion of C3-positive macrophages in the CV-S2-Fr.I group increased by 7.2-fold compared with the control group.

In Vitro Study

Study Snapshot

Polysaccharides extracted from Coriolus versicolor (Turkey Tail mushroom) have a higher macrophage-stimulating effect than lipopolysaccharide, with potential for use in treating inflammatory diseases.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Macrophage-stimulating activity of polysaccharides extracted from fruiting bodies of Coriolus versicolor (Turkey Tail Mushroom).

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References

Characteristics of anti-complementary biopolymer extracted from coriolus versicolor

Anti-complementary biopolymers extracted from Coriolus versicolor fruiting bodies show high anti-complementary activity, with the major pathway being the classical one.

Immunomodulating Components From Chinese Medicines

Chinese herbal medicines have immunomodulating components that enhance immune response, improve quality of life, and potentially treat various diseases.

A subnanogram API LC/MS/MS quantitation method for depsipeptide FR901228 and its preclinical pharmacokinetics.

The developed and validated method for depsipeptide FR901228 quantitation is highly sensitive and specific, enabling preclinical pharmacokinetic studies and demonstrating high accuracy.

Immunolocalization of inducible and constitutive nitric oxide synthases in human bladder cancer.

Bladder carcinoma tissue has high iNOS content, with iNOS in the malignant epithelium and eNOS in tumor stroma playing different roles in tumor angiogenesis and immunosuppression.

Differential effect of protein-bound polysaccharide (PSK) on survival of experimental murine tumors.

Pretreatment with protein-bound polysaccharide (PSK) prolongs survival and inhibits metastasis formation in mice with sarcoma cells, but not in those with LSTRA lymphoma or B16 melanoma.

Citations

Research Progress on the Extraction, Structure, and Bioactivities of Polysaccharides from Coriolus versicolor

Recent research on Coriolus versicolor polysaccharide (CVP) shows promising extraction technology, separation, purification, and structural characterization, but more in-depth research is needed for its potential pharmacological activities.

Classification, structure and mechanism of antiviral polysaccharides derived from edible and medicinal fungus

Antiviral polysaccharides from edible and medicinal fungus show potential in suppressing virus function, immune-modulation, anti-inflammatory, and gut microbiota regulation.

Trametes versicolor (Synn. Coriolus versicolor) Polysaccharides in Cancer Therapy: Targets and Efficacy

Trametes versicolor polysaccharides show potential as an adjuvant therapy for various cancers, with potential for direct cytotoxicity and immunostimulatory effects.

A mixed mushroom control material to facilitate inter-laboratory harmonization of mushroom composition analyses

A mixed mushroom control material (CM) can facilitate inter-laboratory harmonization of mushroom composition analyses, allowing for better comparison of data on nutrients and health benefits among species and within species.

Immunomodulatory Effect of Gymnema sylvestre (R.Br.) Leaf Extract: An In Vitro Study in Rat Model

Gymnema sylvestre leaf extract, containing gymnemic acid, can stimulate both myeloid and lymphoid components of the immune system, potentially restoring innate immune function.