Magnesium acetyl taurate prevents tissue damage and deterioration of prosocial behavior related with vasopressin levels in traumatic brain injured rats.

doi:10.5137/1019-5149.jtn.29272-20.1

Paper

Magnesium acetyl taurate prevents tissue damage and deterioration of prosocial behavior related with vasopressin levels in traumatic brain injured rats.

Published Mar 30, 2020 · Ferda Hosgorler, B. Koc, S. Kizildag

Turkish neurosurgery

Q3 SJR score

3

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0

Influential Citations

Full textSemantic Scholar

Abstract

AIM Mild traumatic brain injury (TBI) may cause cognitive and emotional behavioural disorders. Following head trauma, magnesium concentration in brain tissues decreases; consequently, low magnesium concentrations are responsible for secondary injury processes. We recently demonstrated that magnesium acetyl taurate can effectively pass from systemic circulation into brain tissue, but its functional effectiveness in head trauma is yet unclear. The aim of this study was to investigate the effects of different magnesium forms on tissue damage and behavioural impairment after mild TBI. MATERIAL AND METHODS Rats were divided into 5 groups (control, trauma, magnesium sulphate, magnesium citrate, magnesium acetyl taurate) and following head trauma, empathy-like behaviour, anxiety-like behaviour (elevated plus maze and open field tests), and depression (forced swim test) were measured. The rats were then sacrificed 12 days later. Oxytocin, vasopressin and receptors levels in the amygdala and prefrontal cortex regions were measured. Histopathological damage (with haematoxylin-eosin staining) and apoptosis (with caspase-3 immunohistochemistry) was evaluated. RESULTS Following head trauma, anxiety-like behaviour and depression tests did not change; empathy-like behaviour deteriorated on the 3rd day and improved gradually on the 6th and 12th days. Oxytocin, vasopressin and vasopressin v1b receptor levels decreased in the amygdala; morphological damage and apoptosis were significant. Magnesium acetyl taurate effectively ameliorated histopathological deteriorations and improved vasopressin and v1b receptor levels in the amygdala. Transient deterioration of empathy-like behaviour was impeded only in magnesium taurate treatment. CONCLUSION Magnesium acetyl taurate can be a promising agent candidate to prevent structural and functional damage in traumatic brain injury.

RCT

Animal Study

Study Snapshot

Magnesium acetyl taurate effectively prevents tissue damage and deterioration of prosocial behavior in traumatic brain injured rats, potentially improving recovery outcomes.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Magnesium acetyl taurate prevents tissue damage and deterioration of prosocial behavior related with vasopressin levels in traumatic brain injured rats.

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References

Exploratory, cognitive, and depressive-like behaviors in adult and pediatric mice exposed to controlled cortical impact

Adult mice exposed to controlled cortical impact show spatial memory deficits, but no significant differences in spatial learning impairments were found in pediatric mice.

Regular Aerobic Voluntary Exercise Increased Oxytocin in Female Mice: The Cause of Decreased Anxiety and Increased Empathy-Like Behaviors

Voluntary physical activity reduces anxiety and increases empathy-like behavior in mice, with increased oxytocin levels in female mice but not in male mice.

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Taurine shows potential therapeutic effects against neurological disorders, including neurodegenerative diseases, stroke, epilepsy, and diabetic neuropathy, and may be a promising neuropharmacological option.

Traumatic Brain Injury by Weight-Drop Method Causes Transient Amyloid-β Deposition and Acute Cognitive Deficits in Mice

TBI by weight-drop method causes transient amyloid- deposition and acute cognitive impairments in wild-type mice, but these effects recover within 28 days.

Dose-Dependent Absorption Profile of Different Magnesium Compounds

Magnesium citrate increases muscle and brain magnesium levels dose-independently, while magnesium acetyl taurate increases brain magnesium levels when administered as a split dose.

Citations

In search of prosociality in rodents: A scoping review

Rodents can perform prosocial actions in cooperation, helping, and sharing tasks, but current knowledge is fragmented and many studies neglect behavioral analyses.

The interaction of the circadian and immune system: Desynchrony as a pathological outcome to traumatic brain injury

Traumatic brain injury can lead to disrupted circadian function, leading to negative symptomology and potentially affecting the immune system's response.