Maternal hepatic effects of 1,2,4,5-tetrachlorobenzene in the rat.

doi:10.1016/0013-9351(83)90200-1

Paper

Maternal hepatic effects of 1,2,4,5-tetrachlorobenzene in the rat.

Published Oct 1, 1983 · K. Kitchin, M. T. Ebron

Environmental research

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4

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0

Influential Citations

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

1,2,4,5-tetrachlorobenzene administration during pregnancy can cause increased maternal hepatic enzyme activity, but no maternal deaths were observed.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Maternal hepatic effects of 1,2,4,5-tetrachlorobenzene in the rat.

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References

Maternal hepatic and embryonic effects of 1,2,4-trichlorobenzene in the rat.

1,2,4-trichlorobenzene during pregnancy can cause maternal deaths and decrease body weight gain, while also significantly retarding embryonic development.

Maternal hepatic and embryonic effects of 1,2,3,4-tetrachlorobenzene in the rat.

1,2,3,4-tetrachlorobenzene increases maternal mortality and decreases body weight gain in pregnant rats, with adverse effects on embryonic growth.

Developmental onset of mixed-function oxidase activity in preimplantation mouse embryos.

Late preimplantation mouse embryos (day 3 1/2 of gestation) exhibit enzymatic capability for xenobiotic activation and enzyme induction, but differ in their detoxification mechanisms.

Quantitative evaluation of the promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin of hepatocarcinogenesis from diethylnitrosamine.

TCDD is a potent promoter of hepatocarcinogenesis in rats after receiving a single dose of diethylnitrosamine.

Enhanced aryl hydrocarbon hydroxylase activity after interaction between solubilized cytochrome P-448 and microsomes low in endogenous cytochrome P-450.

Cumene hydroperoxide treatment decreases cytochrome P-450 content and activity, enhancing aryl hydrocarbon hydroxylase activity in microsomes with low cytochrome P-450 content.

Citations

Tetrachlorobenzenes: Evaluation of risks to health from environmental exposure in Canada

Canadian environmental exposure to tetrachlorobenzene isomers is 170-34,000 times less than tolerable daily intakes derived from experimental animals, but data on carcinogenicity remains inconclusive.

Inhalation teratology study on monochlorobenzene in rats and rabbits.

Inhaled monochlorobenzene (MCB) during gestation is not embryotoxic or teratogenic in rats, but may cause slight delays in skeletal development in rabbits.

Maternal hepatic and embryonic effects of 1,2,4-trichlorobenzene in the rat.

1,2,4-trichlorobenzene during pregnancy can cause maternal deaths and decrease body weight gain, while also significantly retarding embryonic development.