Mazindol enhances glucose uptake by rat skeletal muscle.

doi:10.1016/0014-2999(94)90006-X

Paper

DOI: 10.1016/0014-2999(94)90006-X

Mazindol enhances glucose uptake by rat skeletal muscle.

Published Jul 21, 1994 · K. Nagai, N. Nagai, Y. Isojima

European journal of pharmacology

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

Mazindol stimulates glucose uptake in skeletal muscles by acting on glucose transporters in the sarcolemmal membrane, suggesting it may also stimulate glucose transport into the brain and heart through a similar mechanism.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1096/fasebj.6.14.1426762

Regulation of glucose transport in skeletal muscle 1

Exercise increases insulin sensitivity in skeletal muscle, while a high-fat, refined sugar diet causes insulin resistance, with exercise training also increasing insulin sensitivity.

1992·89citations·R. Barnard et al.·The FASEB Journal

The FASEB Journal

DOI: 10.1093/OXFORDJOURNALS.JBCHEM.A123846

Vanadate stimulates D-glucose transport into sarcolemmal vesicles from rat skeletal muscles.

Vanadate stimulates D-glucose uptake into sarcolemmal vesicles in rat skeletal muscles, increasing the intrinsic activity of glucose transporters in a reversible manner.

1992·21citations·N. Okumura et al.·Journal of biochemistry

Journal of biochemistry

DOI: 10.1152/AJPENDO.1991.261.3.E298

Ventromedial hypothalamic stimulation enhances peripheral glucose uptake in anesthetized rats.

Ventromedial hypothalamic stimulation selectively accelerates glucose uptake in certain peripheral tissues, likely through the sympathetic nervous system, without affecting plasma insulin levels.

1991·107citations·M. Sudo et al.·The American journal of physiology

The American journal of physiology

DOI: 10.1152/AJPCELL.1991.260.3.C555

Calcium stimulates glucose transport in skeletal muscle by a pathway independent of contraction.

An increase in cytoplasmic calcium levels too low to cause muscle contraction can stimulate glucose transport activity in skeletal muscle.

1991·191citations·J. Youn et al.·The American journal of physiology

The American journal of physiology

DOI: 10.1016/0031-9384(91)90243-H

Hypothalamic microdialysis of mazindol causes anorexia with increase in synaptic serotonin in rats

Zindol-induced anorexia in rats is partially mediated through serotonergic mechanisms in the hypothalamus.

1991·9citations·N. Shimizu et al.·Physiology & Behavior

Physiology & Behavior

DOI: 10.2337/diacare.39.1.1

Insulin-Mimetic Effects of Vanadate: Possible Implications for Future Treatment of Diabetes

Vanadate ions can mimic insulin's actions and restore glucose metabolism in diabetic rats, potentially improving diabetes treatment without causing liver or kidney toxicity.

1990·349citations·Y. Shechter·Diabetes

Diabetes

DOI: 10.1152/AJPENDO.1987.253.2.E179

Cold exposure potentiates the effect of insulin on in vivo glucose uptake.

Cold exposure and insulin injections together significantly enhance glucose uptake in peripheral tissues, potentially due to enhanced responsiveness and increased tissue blood flow.

1987·80citations·A. Vallerand et al.·The American journal of physiology

The American journal of physiology

DOI: 10.1113/jphysiol.1986.sp016276

Electrophysiological properties and glucose responsiveness of guinea‐pig ventromedial hypothalamic neurones in vitro.

Guinea-pig ventromedial hypothalamic neurones show three distinct membrane properties, with type A neurones showing the quickest response and type B neurones showing the longest half decay time.

1986·85citations·T. Minami et al.·The Journal of Physiology

The Journal of Physiology

DOI: 10.1210/ENDO-117-2-468

Lesions involving the suprachiasmatic nucleus eliminate the glucagon response to intracranial injection of 2-deoxy-D-glucose.

Lesions in the suprachiasmatic nucleus of the hypothalamus eliminate the glucagon response to intracranial injection of 2-deoxy-D-glucose, affecting pancreatic glucagon secretion.

1985·34citations·H. Yamamoto et al.·Endocrinology

Endocrinology

Citations

DOI: 10.1016/S0163-7258(99)00029-7

Dopamine receptors--physiological understanding to therapeutic intervention potential.

Dopamine receptors play a significant role in neuropsychiatry, cardiovascular, and renal diseases, with potential therapeutic benefits in Parkinson's disease, migraine treatment, and heart failure.

1999·241citations·G. Emilien et al.·Pharmacology & therapeutics

Pharmacology & therapeutics

DOI:

Effect of Mazindol in Severely Obese Diet Therapy on Body Weight and Insulin Sensit Patients after aVery-Low-Calorie ivity

Mazindol administration with diet restriction further reduces body weight and improves insulin sensitivity in morbidly obese patients after a very-low-calorie diet.

2006·0citations·T. Nishikawa et al.

DOI: 10.3164/JCBN.24.79

Effects of mazindol on the hyperglycemia induced by intracranial injection of 2-deoxy-D-glucose or by oral glucose load in intact and diabetic rats

Peripheral administration of mazindol reduces blood glucose concentration when it is elevated, potentially enhancing glucose uptake into cells like skeletal muscle.

1998·0citations·S. Chun et al.·Journal of Clinical Biochemistry and Nutrition

Journal of Clinical Biochemistry and Nutrition