J. Giovannetti, C. Kelly, C. Landis
May 1, 1993
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Influential Citations
74
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Journal
Journal of the American Chemical Society
Abstract
In order to probe the structural features that give rise to the high enantioselectivity observed for the hydrogenation of methyl (Z)-α-acetamidocinnamate (MAC) as catalyzed by complexes containing the fragment [Rh(chiral bisphosphine)] + , we have utilized NOE spectroscopy combined with molecular mechanics computations. In addition to the olefinic substrate MAC, we have examined its isopropyl ester (PRAC) and the diolefins norbornadiene and cyclooctadiene. Results are presented for the chiral bisphosphines DIPAMP, CHIRAPHOS, and DIPH