[Mechanism of action of 2-(1'-aminoethyl)-bicyclo[2.2.1]heptane hydrochloride].

Paper

[Mechanism of action of 2-(1'-aminoethyl)-bicyclo[2.2.1]heptane hydrochloride].

Published Mar 1, 1982 · Votiakov Vi, Gribkova Nv, Kazak Nf

Voprosy virusologii

Q4 SJR score

1

Citations

0

Influential Citations

Semantic Scholar

Abstract

: The effect of 2-[1'-aminoethyl)-bicyclo[2.2.1]heptane chlorohydrate on the accumulation of hemagglutinating activity of chick embryo fibroblasts infected with influenza A/FPV/Rostock/34 (Hav1N1) and A/WSN/33 (H0N1) was studied. The drug inhibited hemagglutinines accumulation when added at various intervals after infection, the maximum effect having been observed upon its addition to the maintenance medium immediately after adsorption. Polyacrylamide gel electrophoresis showed the drug to reduce the synthesis of virus-specific proteins of A/FPV and to inhibit considerably the transcriptase activity of A/FPV and A/WSN viruses in vitro.

In Vitro Study

Study Snapshot

2-(1'-aminoethyl)-bicyclo[2.2.1]heptane hydrochloride effectively inhibits hemagglutinin accumulation and reduces virus-specific protein synthesis in influenza A/FPV/Rostock/34 infected chick embryo fibroblast

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

[Mechanism of action of 2-(1'-aminoethyl)-bicyclo[2.2.1]heptane hydrochloride].

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References

Citations

NMR study of diastereoisomerism of 2-(1-aminoethyl)bicyclo[2.2.1]heptane and its hydrochloride (deitiforin)

The diastereoisomerism of 2-(1-aminoethyl)bicyclo[2.2.1]heptane and its hydrochloride (deitiforin) can be identified by two-dimensional 1H and 13C NMR spectroscopy, revealing the presence of ex