Paper
Mechanism of action of niacin.
Published Apr 17, 2008 · V. Kamanna, M. Kashyap
The American journal of cardiology
Q1 SJR score
410
Citations
22
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Highly CitedStudy Snapshot
Niacin reduces triglycerides and increases HDL-containing lipoproteins, improving lipid disorders and cardiovascular disease by inhibiting TG synthesis, reducing oxidative stress, and reducing vascular inflammation.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Mechanism of nicotinic acid transport in human liver cells: experiments with HepG2 cells and primary hepatocytes.
A specific, regulated membrane carrier-mediated system for nicotinic acid transport exists in human liver cells, with acidic pH, temperature, and energy dependence.
2007·37citations·H. Said et al.·American journal of physiology. Cell physiology
American journal of physiology. Cell physiology
Nicotinic acid induces secretion of prostaglandin D2 in human macrophages: an in vitro model of the niacin flush.
Nicotinic acid causes the niacin flush by inducing prostaglandin D2 secretion in human macrophages, which may lead to better strategies to eliminate this side effect.
2007·57citations·C. Meyers et al.·Atherosclerosis
Atherosclerosis
Langerhans cells release prostaglandin D2 in response to nicotinic acid.
Nicotinic acid causes skin flushing by interacting with GPR109A on skin Langerhans cells, leading to the release of prostaglandin D2.
2006·182citations·D. Maciejewski-Lenoir et al.·The Journal of investigative dermatology
The Journal of investigative dermatology
Nicotinic Acid-Induced Flushing Is Mediated by Activation of Epidermal Langerhans Cells
Nicotinic acid-induced flushing is mediated by epidermal Langerhans cells, which activate and produce vasodilatory prostaglandins, potentially offering new strategies to suppress unwanted effects of nicotinic acid.
2006·211citations·Z. Benyó et al.·Molecular Pharmacology
Molecular Pharmacology
Effect of niacin on lipoproteins and atherosclerosis
Niacin reduces triglyceride synthesis, increases HDL, and may have nonlipid-related effects on vascular oxidative and inflammatory processes in atherosclerosis.
2006·23citations·S. Ganji et al.·Future Lipidology
Future Lipidology
Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans.
Antagonism of the prostaglandin D2 receptor 1 (DP1) effectively suppresses nicotinic acid-induced flushing in mice and humans, potentially benefiting patients with dyslipidemia.
2006·269citations·K. Cheng et al.·Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing.
Nicotinic acid-induced flushing is mediated by GPR109A, which involves release of prostaglandins PGE(2) and PGD(2) from immune cells in the skin.
2005·312citations·Z. Benyó et al.·The Journal of clinical investigation
The Journal of clinical investigation
Nicotinic acid: the broad‐spectrum lipid drug. A 50th anniversary review
Nicotinic acid effectively lowers cholesterol levels and raises HDL levels, reducing atherosclerosis progression and heart disease risk.
2005·557citations·Lars A. Carlson·Journal of Internal Medicine
Journal of Internal Medicine
Citations
Nicotinamide: A Multifaceted Molecule in Skin Health and Beyond
Nicotinamide (NAM) supplementation effectively restores cellular energy, repairs DNA damage, and inhibits inflammation, making it a key molecule in chemoprevention, dermatological conditions, and anti-aging skincare.
2025·0citations·L. Camillo et al.·Medicina
Medicina
The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and sarcopenia: A cross-sectional study
The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is significantly associated with an elevated risk of sarcopenia in U.S. adults.
2025·0citations·Xiudeng Yang et al.·Experimental Gerontology
Experimental Gerontology
Leveraging Multifaceted Polyphenol Interactions: An Approach for Hair Loss Mitigation
Tannic acid can effectively reduce hair loss by binding to keratin on the hair surface and allowing controlled release of therapeutic agents, enhancing hair health and mitigating hair loss.
2025·0citations·Eunu Kim et al.·Advanced Materials Interfaces
Advanced Materials Interfaces
Metabolomics analysis of anaphylactoid reactions induced by Xueshuantong injection in normal and immunocompromised mice
Anaphylactoid reactions induced by XSTI are dose-dependent, with immunocompromised mice showing lower sensitivity, and metabolomics research reveals potential pathways inducing these reactions.
2025·0citations·Xiaoqian Guo et al.·Frontiers in Pharmacology
Frontiers in Pharmacology
Management of Severe Hypertriglyceridemia in Pregnancy With Niacin: Reevaluating Safety and Therapeutic Benefits
Niacin, an underutilized treatment with potential side effects, effectively and safely manages severe hypertriglyceridemia in pregnancy when other treatments are insufficient.
2025·0citations·Nisha Suda et al.·Case Reports in Endocrinology
Case Reports in Endocrinology
Advances in the pharmacological management of hyperlipidemia through the use of combination therapies.
Combination therapy with statins shows additive effects on LDL-C, triglycerides, and HDL-C, while niacin and fibrates show no added benefits.
2024·0citations·A. Wierzbicki·Expert opinion on pharmacotherapy
Expert opinion on pharmacotherapy